Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal bipolar neuron | 5 studies | 51% ± 20% | |
| pancreatic A cell | 4 studies | 45% ± 24% | |
| ON-bipolar cell | 4 studies | 38% ± 9% | |
| pancreatic D cell | 3 studies | 61% ± 27% | |
| retinal ganglion cell | 3 studies | 37% ± 8% | |
| rod bipolar cell | 3 studies | 81% ± 6% | |
| enteroendocrine cell | 3 studies | 23% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pancreas | 3 studies | 43% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 1580.66 | 245 / 245 | 97% | 7.59 | 488 / 502 |
| pancreas | 91% | 153.14 | 298 / 328 | 87% | 12.26 | 154 / 178 |
| stomach | 100% | 935.84 | 358 / 359 | 55% | 2.91 | 158 / 286 |
| intestine | 43% | 76.26 | 418 / 966 | 48% | 2.32 | 252 / 527 |
| adrenal gland | 12% | 18.75 | 31 / 258 | 68% | 26.69 | 156 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 58% | 5.10 | 26 / 45 |
| bladder | 43% | 77.86 | 9 / 21 | 14% | 1.43 | 73 / 504 |
| esophagus | 21% | 226.75 | 298 / 1445 | 36% | 1.61 | 66 / 183 |
| uterus | 15% | 71.51 | 26 / 170 | 41% | 3.17 | 186 / 459 |
| skin | 19% | 17.56 | 349 / 1809 | 25% | 1.03 | 120 / 472 |
| adipose | 40% | 161.48 | 486 / 1204 | 0% | 0 | 0 / 0 |
| brain | 30% | 106.46 | 784 / 2642 | 1% | 0.12 | 10 / 705 |
| thymus | 12% | 11.21 | 80 / 653 | 17% | 3.60 | 101 / 605 |
| lung | 0% | 0.17 | 1 / 578 | 28% | 1.79 | 322 / 1155 |
| ovary | 1% | 0.29 | 1 / 180 | 11% | 0.28 | 46 / 430 |
| breast | 6% | 5.60 | 28 / 459 | 3% | 0.14 | 36 / 1118 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.34 | 3 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.08 | 1 / 29 |
| blood vessel | 3% | 2.77 | 36 / 1335 | 0% | 0 | 0 / 0 |
| kidney | 0% | 0 | 0 / 89 | 2% | 0.13 | 16 / 901 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.12 | 6 / 406 |
| muscle | 0% | 0.10 | 1 / 803 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.62 | 1 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.10 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0060037 | Biological process | pharyngeal system development |
| GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0003148 | Biological process | outflow tract septum morphogenesis |
| GO_0008283 | Biological process | cell population proliferation |
| GO_0003266 | Biological process | regulation of secondary heart field cardioblast proliferation |
| GO_0031016 | Biological process | pancreas development |
| GO_0001755 | Biological process | neural crest cell migration |
| GO_0007507 | Biological process | heart development |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0048762 | Biological process | mesenchymal cell differentiation |
| GO_0032735 | Biological process | positive regulation of interleukin-12 production |
| GO_0031333 | Biological process | negative regulation of protein-containing complex assembly |
| GO_0048665 | Biological process | neuron fate specification |
| GO_0060413 | Biological process | atrial septum morphogenesis |
| GO_0003203 | Biological process | endocardial cushion morphogenesis |
| GO_0021524 | Biological process | visceral motor neuron differentiation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0003215 | Biological process | cardiac right ventricle morphogenesis |
| GO_0060931 | Biological process | sinoatrial node cell development |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0032024 | Biological process | positive regulation of insulin secretion |
| GO_0033147 | Biological process | negative regulation of intracellular estrogen receptor signaling pathway |
| GO_0055010 | Biological process | ventricular cardiac muscle tissue morphogenesis |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0048936 | Biological process | peripheral nervous system neuron axonogenesis |
| GO_0007409 | Biological process | axonogenesis |
| GO_0021520 | Biological process | spinal cord motor neuron cell fate specification |
| GO_0021559 | Biological process | trigeminal nerve development |
| GO_0032731 | Biological process | positive regulation of interleukin-1 beta production |
| GO_1901258 | Biological process | positive regulation of macrophage colony-stimulating factor production |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0050728 | Biological process | negative regulation of inflammatory response |
| GO_0032725 | Biological process | positive regulation of granulocyte macrophage colony-stimulating factor production |
| GO_0086091 | Biological process | regulation of heart rate by cardiac conduction |
| GO_0060379 | Biological process | cardiac muscle cell myoblast differentiation |
| GO_0060913 | Biological process | cardiac cell fate determination |
| GO_0010575 | Biological process | positive regulation of vascular endothelial growth factor production |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_0071385 | Biological process | cellular response to glucocorticoid stimulus |
| GO_0071657 | Biological process | positive regulation of granulocyte colony-stimulating factor production |
| GO_0021983 | Biological process | pituitary gland development |
| GO_0032730 | Biological process | positive regulation of interleukin-1 alpha production |
| GO_0003139 | Biological process | secondary heart field specification |
| GO_0031290 | Biological process | retinal ganglion cell axon guidance |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_0021522 | Biological process | spinal cord motor neuron differentiation |
| GO_0048880 | Biological process | sensory system development |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0060384 | Biological process | innervation |
| GO_0032755 | Biological process | positive regulation of interleukin-6 production |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0016922 | Molecular function | nuclear receptor binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0043425 | Molecular function | bHLH transcription factor binding |
| GO_1990841 | Molecular function | promoter-specific chromatin binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000987 | Molecular function | cis-regulatory region sequence-specific DNA binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0030331 | Molecular function | nuclear estrogen receptor binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ISL1 |
| Protein name | Insulin gene enhancer protein ISL-1 (Islet-1) Insulin gene enhancer protein ISL-1 |
| Synonyms | |
| Description | FUNCTION: DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity). . |
| Accessions | ENST00000230658.12 D6RBJ1 ENST00000511384.1 P61371 |
