CAV1 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	46 studies	56% ± 26%	Explore
pericyte	38 studies	61% ± 25%	Explore
fibroblast	32 studies	40% ± 17%	Explore
smooth muscle cell	32 studies	60% ± 24%	Explore
endothelial cell of lymphatic vessel	24 studies	70% ± 16%	Explore
capillary endothelial cell	18 studies	64% ± 26%	Explore
endothelial cell of artery	16 studies	73% ± 25%	Explore
vein endothelial cell	15 studies	65% ± 22%	Explore
endothelial cell of vascular tree	15 studies	65% ± 24%	Explore
basal cell	14 studies	40% ± 21%	Explore
myofibroblast cell	13 studies	62% ± 21%	Explore
type I pneumocyte	12 studies	81% ± 18%	Explore
connective tissue cell	12 studies	38% ± 22%	Explore
mesothelial cell	12 studies	55% ± 21%	Explore
adipocyte	9 studies	43% ± 18%	Explore
type II pneumocyte	7 studies	25% ± 10%	Explore
cardiac muscle cell	6 studies	26% ± 8%	Explore
epithelial cell	6 studies	32% ± 18%	Explore
secretory cell	6 studies	33% ± 14%	Explore
plasma cell	5 studies	26% ± 7%	Explore
melanocyte	5 studies	54% ± 17%	Explore
astrocyte	4 studies	28% ± 11%	Explore
adventitial cell	4 studies	31% ± 10%	Explore
ciliated cell	4 studies	21% ± 5%	Explore
Mueller cell	4 studies	39% ± 13%	Explore
club cell	4 studies	35% ± 23%	Explore
keratinocyte	4 studies	50% ± 12%	Explore
abnormal cell	3 studies	48% ± 31%	Explore
extravillous trophoblast	3 studies	51% ± 14%	Explore
myoepithelial cell	3 studies	59% ± 3%	Explore
muscle cell	3 studies	51% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	30% ± 19%	Explore
heart	6 studies	22% ± 5%	Explore
uterus	5 studies	32% ± 6%	Explore
skin	4 studies	41% ± 14%	Explore
breast	4 studies	28% ± 7%	Explore
intestine	3 studies	20% ± 4%	Explore
placenta	3 studies	37% ± 12%	Explore
prostate	3 studies	32% ± 7%	Explore
adipose	3 studies	44% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	98%	32773.46	1780 / 1809	98%	230.63	462 / 472
thymus	99%	21561.32	644 / 653	94%	257.93	566 / 605
lung	100%	33351.20	577 / 578	86%	119.77	993 / 1155
breast	100%	33816.15	458 / 459	84%	71.05	939 / 1118
uterus	97%	21594.40	165 / 170	76%	115.27	347 / 459
bladder	100%	23287.29	21 / 21	66%	111.88	333 / 504
esophagus	80%	20067.35	1162 / 1445	81%	150.69	149 / 183
prostate	69%	8128.89	169 / 245	77%	54.55	386 / 502
intestine	84%	22077.09	808 / 966	55%	37.02	288 / 527
ovary	83%	9139.06	150 / 180	44%	26.32	190 / 430
stomach	49%	11559.69	176 / 359	62%	42.79	178 / 286
adipose	100%	43889.69	1204 / 1204	0%	0	0 / 0
blood vessel	100%	27817.87	1335 / 1335	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	35.90	1 / 1
heart	99%	16584.17	849 / 861	0%	0	0 / 0
spleen	94%	10369.15	226 / 241	0%	0	0 / 0
pancreas	0%	17.45	1 / 328	88%	98.00	156 / 178
eye	0%	0	0 / 0	88%	67.59	70 / 80
kidney	2%	131.33	2 / 89	79%	157.51	712 / 901
tonsil	0%	0	0 / 0	71%	111.15	32 / 45
brain	0%	29.56	13 / 2642	45%	48.85	318 / 705
muscle	44%	3012.62	355 / 803	0%	0	0 / 0
adrenal gland	2%	88.02	4 / 258	39%	26.02	89 / 230
liver	0%	0	0 / 226	37%	23.07	151 / 406
lymph node	0%	0	0 / 0	34%	16.31	10 / 29
peripheral blood	0%	11.46	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051480	Biological process	regulation of cytosolic calcium ion concentration
GO_0031623	Biological process	receptor internalization
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0046716	Biological process	muscle cell cellular homeostasis
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0046426	Biological process	negative regulation of receptor signaling pathway via JAK-STAT
GO_0098909	Biological process	regulation of cardiac muscle cell action potential involved in regulation of contraction
GO_0003057	Biological process	regulation of the force of heart contraction by chemical signal
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0010608	Biological process	post-transcriptional regulation of gene expression
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0043085	Biological process	positive regulation of catalytic activity
GO_0048550	Biological process	negative regulation of pinocytosis
GO_0030857	Biological process	negative regulation of epithelial cell differentiation
GO_0033484	Biological process	intracellular nitric oxide homeostasis
GO_0016050	Biological process	vesicle organization
GO_0001666	Biological process	response to hypoxia
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0061099	Biological process	negative regulation of protein tyrosine kinase activity
GO_0033137	Biological process	negative regulation of peptidyl-serine phosphorylation
GO_0098903	Biological process	regulation of membrane repolarization during action potential
GO_1904294	Biological process	positive regulation of ERAD pathway
GO_0042310	Biological process	vasoconstriction
GO_0052547	Biological process	regulation of peptidase activity
GO_0006816	Biological process	calcium ion transport
GO_0051592	Biological process	response to calcium ion
GO_1900027	Biological process	regulation of ruffle assembly
GO_0030879	Biological process	mammary gland development
GO_0001525	Biological process	angiogenesis
GO_0097190	Biological process	apoptotic signaling pathway
GO_0007519	Biological process	skeletal muscle tissue development
GO_0002931	Biological process	response to ischemia
GO_0000165	Biological process	MAPK cascade
GO_0072584	Biological process	caveolin-mediated endocytosis
GO_0009617	Biological process	response to bacterium
GO_0031295	Biological process	T cell costimulation
GO_0010628	Biological process	positive regulation of gene expression
GO_2001244	Biological process	positive regulation of intrinsic apoptotic signaling pathway
GO_0019217	Biological process	regulation of fatty acid metabolic process
GO_2000811	Biological process	negative regulation of anoikis
GO_0060056	Biological process	mammary gland involution
GO_1903598	Biological process	positive regulation of gap junction assembly
GO_0071711	Biological process	basement membrane organization
GO_0001937	Biological process	negative regulation of endothelial cell proliferation
GO_0019915	Biological process	lipid storage
GO_0006809	Biological process	nitric oxide biosynthetic process
GO_0071375	Biological process	cellular response to peptide hormone stimulus
GO_0048144	Biological process	fibroblast proliferation
GO_0086091	Biological process	regulation of heart rate by cardiac conduction
GO_0031398	Biological process	positive regulation of protein ubiquitination
GO_1901844	Biological process	regulation of cell communication by electrical coupling involved in cardiac conduction
GO_0001960	Biological process	negative regulation of cytokine-mediated signaling pathway
GO_0034141	Biological process	positive regulation of toll-like receptor 3 signaling pathway
GO_0042532	Biological process	negative regulation of tyrosine phosphorylation of STAT protein
GO_0060355	Biological process	positive regulation of cell adhesion molecule production
GO_2001238	Biological process	positive regulation of extrinsic apoptotic signaling pathway
GO_0051899	Biological process	membrane depolarization
GO_1903361	Biological process	protein localization to basolateral plasma membrane
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0045907	Biological process	positive regulation of vasoconstriction
GO_0001570	Biological process	vasculogenesis
GO_0006641	Biological process	triglyceride metabolic process
GO_0098911	Biological process	regulation of ventricular cardiac muscle cell action potential
GO_0071360	Biological process	cellular response to exogenous dsRNA
GO_0038016	Biological process	insulin receptor internalization
GO_0032570	Biological process	response to progesterone
GO_0030301	Biological process	cholesterol transport
GO_0055074	Biological process	calcium ion homeostasis
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0043627	Biological process	response to estrogen
GO_0010524	Biological process	positive regulation of calcium ion transport into cytosol
GO_1901380	Biological process	negative regulation of potassium ion transmembrane transport
GO_0006940	Biological process	regulation of smooth muscle contraction
GO_0071218	Biological process	cellular response to misfolded protein
GO_1900085	Biological process	negative regulation of peptidyl-tyrosine autophosphorylation
GO_0045019	Biological process	negative regulation of nitric oxide biosynthetic process
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0051649	Biological process	establishment of localization in cell
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0070836	Biological process	caveola assembly
GO_0030193	Biological process	regulation of blood coagulation
GO_0044860	Biological process	protein localization to plasma membrane raft
GO_0060546	Biological process	negative regulation of necroptotic process
GO_0030335	Biological process	positive regulation of cell migration
GO_0038166	Biological process	angiotensin-activated signaling pathway
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0030154	Biological process	cell differentiation
GO_0002067	Biological process	glandular epithelial cell differentiation
GO_0001935	Biological process	endothelial cell proliferation
GO_0019065	Biological process	receptor-mediated endocytosis of virus by host cell
GO_0010875	Biological process	positive regulation of cholesterol efflux
GO_0043409	Biological process	negative regulation of MAPK cascade
GO_0071455	Biological process	cellular response to hyperoxia
GO_1903609	Biological process	negative regulation of inward rectifier potassium channel activity
GO_0015031	Biological process	protein transport
GO_0008104	Biological process	protein localization
GO_0007595	Biological process	lactation
GO_2000535	Biological process	regulation of entry of bacterium into host cell
GO_0032507	Biological process	maintenance of protein location in cell
GO_0042632	Biological process	cholesterol homeostasis
GO_0031397	Biological process	negative regulation of protein ubiquitination
GO_0045121	Cellular component	membrane raft
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005768	Cellular component	endosome
GO_0031901	Cellular component	early endosome membrane
GO_0005886	Cellular component	plasma membrane
GO_0005811	Cellular component	lipid droplet
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0016020	Cellular component	membrane
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005794	Cellular component	Golgi apparatus
GO_0000139	Cellular component	Golgi membrane
GO_0005929	Cellular component	cilium
GO_0002095	Cellular component	caveolar macromolecular signaling complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005901	Cellular component	caveola
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0002080	Cellular component	acrosomal membrane
GO_0042383	Cellular component	sarcolemma
GO_0005925	Cellular component	focal adhesion
GO_0005938	Cellular component	cell cortex
GO_0015485	Molecular function	cholesterol binding
GO_0050998	Molecular function	nitric-oxide synthase binding
GO_0042802	Molecular function	identical protein binding
GO_0051117	Molecular function	ATPase binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0140311	Molecular function	protein sequestering activity
GO_0060090	Molecular function	molecular adaptor activity
GO_0005102	Molecular function	signaling receptor binding
GO_0005113	Molecular function	patched binding
GO_0019899	Molecular function	enzyme binding
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0030292	Molecular function	protein tyrosine kinase inhibitor activity
GO_0008142	Molecular function	oxysterol binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0070320	Molecular function	inward rectifier potassium channel inhibitor activity
GO_0005515	Molecular function	protein binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0019901	Molecular function	protein kinase binding
GO_0016504	Molecular function	peptidase activator activity
GO_0031267	Molecular function	small GTPase binding

Gene name	CAV1
Protein name	Caveolin-1 Alternative protein CAV1 Caveolin 1 Caveolin
Synonyms	tcag7.24 hCG_39088 CAV
Description	FUNCTION: May act as a scaffolding protein within caveolar membranes . Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae . Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner . Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation . Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). . FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. . FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. . FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. .
Accessions	ENST00000341049.7 [Q03135-1] C9JKI3 ENST00000393468.1 [Q03135-2] Q03135 Q2TNI1 ENST00000393470.1 A0A7P0YWJ6 ENST00000451122.5 L8EC89 ENST00000405348.6 [Q03135-2] ENST00000393467.1 [Q03135-2] E9PCT5 ENST00000456473.5 ENST00000614113.5 F8WDM7

CAV1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review