TLE2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0016055Biological processWnt signaling pathway
GO_0009887Biological processanimal organ morphogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0005615Cellular componentextracellular space
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTLE2
Protein nameTLE family member 2, transcriptional corepressor
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)
Synonyms
DescriptionFUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). .

AccessionsK7ESD8
ENST00000590536.5
ENST00000587137.5
ENST00000586422.5
ENST00000426948.6 [Q04725-3]
ENST00000591529.5 [Q04725-3]
ENST00000591457.5
K7EPD4
K7EJR7
K7EPF3
K7EK93
ENST00000592584.1
K7EMK7
ENST00000262953.11 [Q04725-1]
ENST00000589364.5
Q04725
ENST00000443826.7 [Q04725-2]