I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| extravillous trophoblast | 3 studies | 58% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| extravillous trophoblast | 3 studies | 58% ± 5% |
Insufficient scRNA-seq data for expression of NOTUM at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 99% | 551.33 | 224 / 226 | 66% | 103.92 | 268 / 406 |
| lung | 99% | 193.30 | 570 / 578 | 47% | 34.70 | 544 / 1155 |
| brain | 88% | 76.06 | 2323 / 2642 | 33% | 1.42 | 235 / 705 |
| stomach | 38% | 31.41 | 137 / 359 | 63% | 128.03 | 181 / 286 |
| muscle | 98% | 287.76 | 783 / 803 | 0% | 0 | 0 / 0 |
| bladder | 57% | 169.76 | 12 / 21 | 38% | 55.32 | 192 / 504 |
| skin | 71% | 151.97 | 1287 / 1809 | 16% | 3.26 | 74 / 472 |
| intestine | 9% | 3.88 | 89 / 966 | 72% | 97.97 | 379 / 527 |
| pancreas | 24% | 8.23 | 79 / 328 | 51% | 4.83 | 90 / 178 |
| esophagus | 22% | 9.98 | 322 / 1445 | 49% | 45.09 | 89 / 183 |
| ovary | 5% | 5.28 | 9 / 180 | 59% | 32.41 | 255 / 430 |
| prostate | 51% | 29.11 | 126 / 245 | 7% | 1.60 | 37 / 502 |
| uterus | 21% | 42.26 | 36 / 170 | 31% | 28.76 | 144 / 459 |
| kidney | 48% | 62.31 | 43 / 89 | 3% | 0.38 | 24 / 901 |
| adrenal gland | 24% | 12.94 | 63 / 258 | 15% | 2.65 | 35 / 230 |
| spleen | 39% | 17.19 | 95 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 27% | 1.93 | 12 / 45 |
| heart | 25% | 10.67 | 218 / 861 | 0% | 0 | 0 / 0 |
| breast | 6% | 2.18 | 27 / 459 | 11% | 0.92 | 125 / 1118 |
| adipose | 6% | 3.66 | 78 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 2% | 0.51 | 11 / 653 | 3% | 1.03 | 19 / 605 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.07 | 1 / 29 |
| peripheral blood | 3% | 1.34 | 32 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 0.94 | 19 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030178 | Biological process | negative regulation of Wnt signaling pathway |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0030500 | Biological process | regulation of bone mineralization |
| GO_0060348 | Biological process | bone development |
| GO_1990697 | Biological process | protein depalmitoleylation |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0005576 | Cellular component | extracellular region |
| GO_0004629 | Molecular function | phospholipase C activity |
| GO_1990699 | Molecular function | palmitoleyl hydrolase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NOTUM |
| Protein name | Palmitoleoyl-protein carboxylesterase NOTUM (EC 3.1.1.98) (hNOTUM) [Wnt protein] O-palmitoleoyl-L-serine hydrolase (EC 3.1.1.98) |
| Synonyms | OK/SW-CL.30 |
| Description | FUNCTION: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors . . |
| Accessions | ENST00000425009.1 ENST00000409678.8 C9JYG8 Q6P988 ENST00000477214.5 K7EIG3 |
