Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 27 studies | 35% ± 17% | |
fibroblast | 26 studies | 32% ± 13% | |
non-classical monocyte | 24 studies | 46% ± 19% | |
astrocyte | 18 studies | 54% ± 22% | |
pericyte | 15 studies | 27% ± 12% | |
oligodendrocyte precursor cell | 14 studies | 46% ± 18% | |
macrophage | 14 studies | 28% ± 9% | |
epithelial cell | 12 studies | 38% ± 18% | |
smooth muscle cell | 12 studies | 30% ± 12% | |
microglial cell | 11 studies | 28% ± 8% | |
adipocyte | 11 studies | 63% ± 18% | |
basal cell | 9 studies | 37% ± 22% | |
alveolar macrophage | 8 studies | 46% ± 21% | |
connective tissue cell | 8 studies | 29% ± 10% | |
goblet cell | 7 studies | 30% ± 21% | |
myeloid cell | 7 studies | 22% ± 5% | |
myofibroblast cell | 7 studies | 30% ± 15% | |
ciliated cell | 7 studies | 29% ± 10% | |
endothelial cell of lymphatic vessel | 7 studies | 39% ± 13% | |
monocyte | 7 studies | 45% ± 18% | |
club cell | 6 studies | 38% ± 16% | |
type I pneumocyte | 6 studies | 26% ± 9% | |
oligodendrocyte | 6 studies | 28% ± 9% | |
endothelial cell of artery | 5 studies | 25% ± 8% | |
mesothelial cell | 5 studies | 34% ± 17% | |
Mueller cell | 5 studies | 43% ± 22% | |
endothelial cell of vascular tree | 5 studies | 34% ± 22% | |
glutamatergic neuron | 5 studies | 34% ± 16% | |
type II pneumocyte | 5 studies | 35% ± 9% | |
cholangiocyte | 4 studies | 54% ± 21% | |
hepatocyte | 4 studies | 64% ± 27% | |
podocyte | 4 studies | 28% ± 4% | |
cardiac muscle cell | 4 studies | 22% ± 2% | |
respiratory goblet cell | 4 studies | 48% ± 17% | |
neuron | 4 studies | 45% ± 19% | |
GABAergic neuron | 3 studies | 27% ± 6% | |
glial cell | 3 studies | 29% ± 11% | |
extravillous trophoblast | 3 studies | 59% ± 11% | |
vein endothelial cell | 3 studies | 46% ± 22% | |
lymphocyte | 3 studies | 18% ± 2% | |
abnormal cell | 3 studies | 32% ± 20% | |
retinal pigment epithelial cell | 3 studies | 44% ± 13% | |
muscle cell | 3 studies | 29% ± 14% | |
neural progenitor cell | 3 studies | 44% ± 10% | |
ependymal cell | 3 studies | 57% ± 20% | |
adventitial cell | 3 studies | 27% ± 9% | |
chondrocyte | 3 studies | 44% ± 17% | |
transit amplifying cell | 3 studies | 43% ± 37% | |
mononuclear phagocyte | 3 studies | 22% ± 4% | |
interneuron | 3 studies | 31% ± 3% | |
mucus secreting cell | 3 studies | 56% ± 7% | |
myoepithelial cell | 3 studies | 43% ± 26% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1866.19 | 1445 / 1445 | 100% | 26.43 | 183 / 183 |
ovary | 100% | 3536.59 | 180 / 180 | 100% | 20.40 | 430 / 430 |
lung | 100% | 2471.56 | 577 / 578 | 100% | 17.31 | 1153 / 1155 |
prostate | 100% | 2353.09 | 244 / 245 | 100% | 14.16 | 502 / 502 |
intestine | 100% | 3457.69 | 966 / 966 | 99% | 27.72 | 524 / 527 |
uterus | 100% | 4174.36 | 170 / 170 | 99% | 14.41 | 456 / 459 |
stomach | 100% | 2263.52 | 359 / 359 | 99% | 28.08 | 283 / 286 |
pancreas | 99% | 1117.02 | 326 / 328 | 99% | 24.31 | 177 / 178 |
thymus | 100% | 2475.86 | 653 / 653 | 99% | 16.15 | 597 / 605 |
bladder | 100% | 2353.29 | 21 / 21 | 98% | 16.43 | 496 / 504 |
kidney | 100% | 1434.89 | 89 / 89 | 98% | 12.94 | 884 / 901 |
liver | 100% | 2045.70 | 226 / 226 | 98% | 10.70 | 396 / 406 |
breast | 100% | 4607.21 | 459 / 459 | 97% | 16.72 | 1083 / 1118 |
skin | 100% | 2593.65 | 1809 / 1809 | 95% | 11.17 | 448 / 472 |
adrenal gland | 100% | 1506.41 | 258 / 258 | 94% | 8.25 | 217 / 230 |
brain | 90% | 1020.25 | 2389 / 2642 | 100% | 17.50 | 703 / 705 |
adipose | 100% | 4281.99 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4253.44 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 2936.83 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.27 | 1 / 1 |
heart | 97% | 1108.38 | 836 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 10.70 | 43 / 45 |
eye | 0% | 0 | 0 / 0 | 95% | 8.63 | 76 / 80 |
muscle | 81% | 611.59 | 648 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 45% | 2.06 | 13 / 29 |
peripheral blood | 35% | 269.72 | 329 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010909 | Biological process | positive regulation of heparan sulfate proteoglycan biosynthetic process |
GO_0031016 | Biological process | pancreas development |
GO_0045721 | Biological process | negative regulation of gluconeogenesis |
GO_0009749 | Biological process | response to glucose |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0032092 | Biological process | positive regulation of protein binding |
GO_0048625 | Biological process | myoblast fate commitment |
GO_0032350 | Biological process | regulation of hormone metabolic process |
GO_2000675 | Biological process | negative regulation of type B pancreatic cell apoptotic process |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0043433 | Biological process | negative regulation of DNA-binding transcription factor activity |
GO_0032024 | Biological process | positive regulation of insulin secretion |
GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
GO_0060070 | Biological process | canonical Wnt signaling pathway |
GO_0048660 | Biological process | regulation of smooth muscle cell proliferation |
GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
GO_0001568 | Biological process | blood vessel development |
GO_1900182 | Biological process | positive regulation of protein localization to nucleus |
GO_2001237 | Biological process | negative regulation of extrinsic apoptotic signaling pathway |
GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0043570 | Biological process | maintenance of DNA repeat elements |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0042593 | Biological process | glucose homeostasis |
GO_0045444 | Biological process | fat cell differentiation |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0032993 | Cellular component | protein-DNA complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0071664 | Cellular component | catenin-TCF7L2 complex |
GO_0016605 | Cellular component | PML body |
GO_0070369 | Cellular component | beta-catenin-TCF7L2 complex |
GO_1990907 | Cellular component | beta-catenin-TCF complex |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0016922 | Molecular function | nuclear receptor binding |
GO_1990841 | Molecular function | promoter-specific chromatin binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_0000976 | Molecular function | transcription cis-regulatory region binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0008013 | Molecular function | beta-catenin binding |
GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0045295 | Molecular function | gamma-catenin binding |
GO_0005515 | Molecular function | protein binding |
GO_0070016 | Molecular function | armadillo repeat domain binding |
Gene name | TCF7L2 |
Protein name | Transcription factor 7-like 2 TCF7L2 protein (Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_e) TCF7L2 isoform pFC8A_TCF7L2_ex1-11-13-14 (Transcription factor 7 like 2) (Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_i) Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) Transcription factor 7 like 2 T-cell factor-4 variant C T-cell factor-4 variant H T-cell factor-4 variant E Transcription factor 7 like 2 (cDNA, FLJ79010, highly similar to Transcription factor 7-like 2) Transcription factor 7 like 2 isoform E4 TCF7L2 isoform pFC8A_TCF7L2_H7_ex1-11-13-13b (Transcription factor 7 like 2) Transcription factor 7 like 2 isoform E1 T-cell factor-4 variant L T-cell factor-4 variant D TCF7L2 isoform pFC8A_TCF7L2_A3,ex1-12,13,13a (Transcription factor 7 like 2) T-cell factor-4 variant F |
Synonyms | hCG_40998 TCF4 |
Description | FUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. . |
Accessions | E2GH13 E2GH23 H0YEE5 B5BU30 ENST00000629706.2 ENST00000369386.5 A0A2Z5HTM8 Q5VVR7 Q9NQB0 ENST00000346198.5 ENST00000545257.6 A0A994J4F0 ENST00000534894.5 A0A994J711 A0A0A0MTL7 E2GH15 Q5VVR8 ENST00000470254.1 ENST00000704420.1 ENST00000352065.10 [Q9NQB0-12] A0A2Z5HTN9 A0A1B0GVE1 C6ZRJ7 ENST00000355717.9 [Q9NQB0-11] ENST00000538897.5 [Q9NQB0-6] E2GH18 ENST00000369389.7 ENST00000704422.1 Q6FHW4 A0A0D9SGH8 ENST00000637574.2 Q5JRY3 E2GH26 ENST00000480888.1 C6ZRK5 ENST00000369395.6 ENST00000369397.8 [Q9NQB0-8] E2GH16 ENST00000355995.9 [Q9NQB0-1] Q5JRY4 ENST00000704414.1 A0A1B0GU84 Q5VVR5 ENST00000627217.3 [Q9NQB0-7] ENST00000277945.12 ENST00000349937.8 |