TCF7L2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010909Biological processpositive regulation of heparan sulfate proteoglycan biosynthetic process
GO_0031016Biological processpancreas development
GO_0045721Biological processnegative regulation of gluconeogenesis
GO_0009749Biological processresponse to glucose
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032092Biological processpositive regulation of protein binding
GO_0048625Biological processmyoblast fate commitment
GO_0032350Biological processregulation of hormone metabolic process
GO_2000675Biological processnegative regulation of type B pancreatic cell apoptotic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0032024Biological processpositive regulation of insulin secretion
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0048660Biological processregulation of smooth muscle cell proliferation
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0001568Biological processblood vessel development
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0043570Biological processmaintenance of DNA repeat elements
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0042593Biological processglucose homeostasis
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032993Cellular componentprotein-DNA complex
GO_0005654Cellular componentnucleoplasm
GO_0071664Cellular componentcatenin-TCF7L2 complex
GO_0016605Cellular componentPML body
GO_0070369Cellular componentbeta-catenin-TCF7L2 complex
GO_1990907Cellular componentbeta-catenin-TCF complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0016922Molecular functionnuclear receptor binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0019901Molecular functionprotein kinase binding
GO_0008013Molecular functionbeta-catenin binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0045295Molecular functiongamma-catenin binding
GO_0005515Molecular functionprotein binding
GO_0070016Molecular functionarmadillo repeat domain binding

IV. Literature review

[source]
Gene nameTCF7L2
Protein nameTranscription factor 7-like 2
TCF7L2 protein (Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_e)
TCF7L2 isoform pFC8A_TCF7L2_ex1-11-13-14 (Transcription factor 7 like 2) (Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_i)
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
Transcription factor 7 like 2
T-cell factor-4 variant C
T-cell factor-4 variant H
T-cell factor-4 variant E
Transcription factor 7 like 2 (cDNA, FLJ79010, highly similar to Transcription factor 7-like 2)
Transcription factor 7 like 2 isoform E4
TCF7L2 isoform pFC8A_TCF7L2_H7_ex1-11-13-13b (Transcription factor 7 like 2)
Transcription factor 7 like 2 isoform E1
T-cell factor-4 variant L
T-cell factor-4 variant D
TCF7L2 isoform pFC8A_TCF7L2_A3,ex1-12,13,13a (Transcription factor 7 like 2)
T-cell factor-4 variant F
SynonymshCG_40998
TCF4
DescriptionFUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. .

AccessionsE2GH13
E2GH23
H0YEE5
B5BU30
ENST00000629706.2
ENST00000369386.5
A0A2Z5HTM8
Q5VVR7
Q9NQB0
ENST00000346198.5
ENST00000545257.6
A0A994J4F0
ENST00000534894.5
A0A994J711
A0A0A0MTL7
E2GH15
Q5VVR8
ENST00000470254.1
ENST00000704420.1
ENST00000352065.10 [Q9NQB0-12]
A0A2Z5HTN9
A0A1B0GVE1
C6ZRJ7
ENST00000355717.9 [Q9NQB0-11]
ENST00000538897.5 [Q9NQB0-6]
E2GH18
ENST00000369389.7
ENST00000704422.1
Q6FHW4
A0A0D9SGH8
ENST00000637574.2
Q5JRY3
E2GH26
ENST00000480888.1
C6ZRK5
ENST00000369395.6
ENST00000369397.8 [Q9NQB0-8]
E2GH16
ENST00000355995.9 [Q9NQB0-1]
Q5JRY4
ENST00000704414.1
A0A1B0GU84
Q5VVR5
ENST00000627217.3 [Q9NQB0-7]
ENST00000277945.12
ENST00000349937.8