I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type II pneumocyte | 5 studies | 20% ± 7% | |
| pericyte | 4 studies | 22% ± 3% | |
| endothelial cell of lymphatic vessel | 3 studies | 32% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type II pneumocyte | 5 studies | 20% ± 7% | |
| pericyte | 4 studies | 22% ± 3% | |
| endothelial cell of lymphatic vessel | 3 studies | 32% ± 8% |
Insufficient scRNA-seq data for expression of BMP2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 94% | 498.48 | 307 / 328 | 96% | 25.62 | 171 / 178 |
| stomach | 100% | 1138.19 | 359 / 359 | 88% | 23.63 | 252 / 286 |
| thymus | 100% | 1843.84 | 652 / 653 | 86% | 24.53 | 522 / 605 |
| intestine | 97% | 1199.32 | 939 / 966 | 88% | 20.53 | 465 / 527 |
| lung | 100% | 2313.07 | 578 / 578 | 82% | 21.12 | 943 / 1155 |
| esophagus | 94% | 550.98 | 1354 / 1445 | 87% | 29.93 | 160 / 183 |
| kidney | 94% | 597.70 | 84 / 89 | 84% | 18.22 | 753 / 901 |
| bladder | 95% | 2034.48 | 20 / 21 | 72% | 21.14 | 362 / 504 |
| uterus | 92% | 461.89 | 156 / 170 | 72% | 21.71 | 332 / 459 |
| liver | 62% | 295.84 | 140 / 226 | 63% | 12.45 | 255 / 406 |
| brain | 31% | 91.26 | 818 / 2642 | 92% | 56.96 | 647 / 705 |
| breast | 99% | 1076.29 | 455 / 459 | 9% | 1.27 | 101 / 1118 |
| prostate | 80% | 326.38 | 197 / 245 | 22% | 2.04 | 108 / 502 |
| spleen | 100% | 1260.84 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 41.73 | 1 / 1 |
| adipose | 100% | 1528.78 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 682.69 | 1315 / 1335 | 0% | 0 | 0 / 0 |
| skin | 74% | 1114.00 | 1343 / 1809 | 14% | 5.12 | 68 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 23.97 | 37 / 45 |
| heart | 81% | 383.77 | 701 / 861 | 0% | 0 | 0 / 0 |
| ovary | 69% | 302.10 | 124 / 180 | 6% | 0.58 | 25 / 430 |
| adrenal gland | 46% | 141.15 | 119 / 258 | 15% | 2.25 | 34 / 230 |
| muscle | 51% | 164.05 | 412 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.67 | 2 / 29 |
| peripheral blood | 3% | 14.55 | 31 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.07 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0001658 | Biological process | branching involved in ureteric bud morphogenesis |
| GO_0010894 | Biological process | negative regulation of steroid biosynthetic process |
| GO_0006954 | Biological process | inflammatory response |
| GO_0045786 | Biological process | negative regulation of cell cycle |
| GO_0035360 | Biological process | positive regulation of peroxisome proliferator activated receptor signaling pathway |
| GO_0002062 | Biological process | chondrocyte differentiation |
| GO_0003203 | Biological process | endocardial cushion morphogenesis |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0060128 | Biological process | corticotropin hormone secreting cell differentiation |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0032348 | Biological process | negative regulation of aldosterone biosynthetic process |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_2000726 | Biological process | negative regulation of cardiac muscle cell differentiation |
| GO_0055008 | Biological process | cardiac muscle tissue morphogenesis |
| GO_0010922 | Biological process | positive regulation of phosphatase activity |
| GO_0001666 | Biological process | response to hypoxia |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0043407 | Biological process | negative regulation of MAP kinase activity |
| GO_0001501 | Biological process | skeletal system development |
| GO_0045778 | Biological process | positive regulation of ossification |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0035054 | Biological process | embryonic heart tube anterior/posterior pattern specification |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0003210 | Biological process | cardiac atrium formation |
| GO_0071773 | Biological process | cellular response to BMP stimulus |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0042482 | Biological process | positive regulation of odontogenesis |
| GO_0051042 | Biological process | negative regulation of calcium-independent cell-cell adhesion |
| GO_1901331 | Biological process | positive regulation of odontoblast differentiation |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0009617 | Biological process | response to bacterium |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0003331 | Biological process | positive regulation of extracellular matrix constituent secretion |
| GO_0048711 | Biological process | positive regulation of astrocyte differentiation |
| GO_0045599 | Biological process | negative regulation of fat cell differentiation |
| GO_0060391 | Biological process | positive regulation of SMAD protein signal transduction |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_0048708 | Biological process | astrocyte differentiation |
| GO_1900745 | Biological process | positive regulation of p38MAPK cascade |
| GO_0072138 | Biological process | mesenchymal cell proliferation involved in ureteric bud development |
| GO_0045165 | Biological process | cell fate commitment |
| GO_0042487 | Biological process | regulation of odontogenesis of dentin-containing tooth |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0043569 | Biological process | negative regulation of insulin-like growth factor receptor signaling pathway |
| GO_0060348 | Biological process | bone development |
| GO_0030177 | Biological process | positive regulation of Wnt signaling pathway |
| GO_1900159 | Biological process | positive regulation of bone mineralization involved in bone maturation |
| GO_0033690 | Biological process | positive regulation of osteoblast proliferation |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_0036305 | Biological process | ameloblast differentiation |
| GO_0030316 | Biological process | osteoclast differentiation |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_0032092 | Biological process | positive regulation of protein binding |
| GO_0003181 | Biological process | atrioventricular valve morphogenesis |
| GO_0021978 | Biological process | telencephalon regionalization |
| GO_1905222 | Biological process | atrioventricular canal morphogenesis |
| GO_1905072 | Biological process | cardiac jelly development |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0031648 | Biological process | protein destabilization |
| GO_0060485 | Biological process | mesenchyme development |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0060129 | Biological process | thyroid-stimulating hormone-secreting cell differentiation |
| GO_0003133 | Biological process | endodermal-mesodermal cell signaling |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0061036 | Biological process | positive regulation of cartilage development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0001837 | Biological process | epithelial to mesenchymal transition |
| GO_0006029 | Biological process | proteoglycan metabolic process |
| GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO_0003272 | Biological process | endocardial cushion formation |
| GO_0060039 | Biological process | pericardium development |
| GO_0007507 | Biological process | heart development |
| GO_0055007 | Biological process | cardiac muscle cell differentiation |
| GO_0048762 | Biological process | mesenchymal cell differentiation |
| GO_0048839 | Biological process | inner ear development |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0060426 | Biological process | lung vasculature development |
| GO_0060317 | Biological process | cardiac epithelial to mesenchymal transition |
| GO_0003129 | Biological process | heart induction |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_2000065 | Biological process | negative regulation of cortisol biosynthetic process |
| GO_0045600 | Biological process | positive regulation of fat cell differentiation |
| GO_0048662 | Biological process | negative regulation of smooth muscle cell proliferation |
| GO_0030282 | Biological process | bone mineralization |
| GO_0003176 | Biological process | aortic valve development |
| GO_0035051 | Biological process | cardiocyte differentiation |
| GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_0030501 | Biological process | positive regulation of bone mineralization |
| GO_0071407 | Biological process | cellular response to organic cyclic compound |
| GO_0021537 | Biological process | telencephalon development |
| GO_0009986 | Cellular component | cell surface |
| GO_0005576 | Cellular component | extracellular region |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0070724 | Cellular component | BMP receptor complex |
| GO_0005615 | Cellular component | extracellular space |
| GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0070700 | Molecular function | BMP receptor binding |
| GO_0019211 | Molecular function | phosphatase activator activity |
| GO_0005125 | Molecular function | cytokine activity |
| GO_0039706 | Molecular function | co-receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0008083 | Molecular function | growth factor activity |
| Gene name | BMP2 |
| Protein name | Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A) Bone morphogenetic protein 2 BMP2 protein |
| Synonyms | BMP2A hCG_39524 |
| Description | FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis . Induces cartilage and bone formation . Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 . Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A . In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 . Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation . Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation . Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). . |
| Accessions | C8C061 P12643 C8C065 ENST00000378827.5 C8C071 U3N491 C8C066 C8C064 C8C060 C8C068 C8C063 C8C069 |
