DKKL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DKKL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DKKL1 at tissue level.

III. Associated gene sets

GO_2000225Biological processnegative regulation of testosterone biosynthetic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0009653Biological processanatomical structure morphogenesis
GO_0007341Biological processpenetration of zona pellucida
GO_0005615Cellular componentextracellular space
GO_0001669Cellular componentacrosomal vesicle
GO_0048019Molecular functionreceptor antagonist activity
GO_0039706Molecular functionco-receptor binding

IV. Literature review

[source]
Gene nameDKKL1
Protein nameDickkopf like acrosomal protein 1
Dickkopf-like protein 1 (Cancer/testis antigen 34) (CT34) (Protein soggy-1) (SGY-1)
SynonymsUNQ735/PRO1429
SGY1
DescriptionFUNCTION: Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility. .

AccessionsM0R1E5
ENST00000597546.1
M0R2X7
M0QZP1
Q9UK85
M0R1Q7
ENST00000594268.1
M0QYJ2
ENST00000598682.1
ENST00000597873.5
ENST00000596402.1
ENST00000221498.7