IGFBP6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0016477Biological processcell migration
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0043567Biological processregulation of insulin-like growth factor receptor signaling pathway
GO_0042568Cellular componentinsulin-like growth factor binary complex
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0031995Molecular functioninsulin-like growth factor II binding
GO_0042802Molecular functionidentical protein binding
GO_0005102Molecular functionsignaling receptor binding
GO_0001968Molecular functionfibronectin binding
GO_0005515Molecular functionprotein binding
GO_0031994Molecular functioninsulin-like growth factor I binding

IV. Literature review

[source]
Gene nameIGFBP6
Protein nameInsulin like growth factor binding protein 6
Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6)
Insulin-like growth factor binding protein 6
SynonymsIBP6
DescriptionFUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration . .

AccessionsENST00000301464.4
ENST00000548547.5
ENST00000549628.1
P24592
Q9H2B5
F8VVA5
A0A3B3IUE0
ENST00000548176.1
ENST00000650247.1
F8VYK9