FOXO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000177Biological processregulation of neural precursor cell proliferation
GO_0097009Biological processenergy homeostasis
GO_1903243Biological processnegative regulation of cardiac muscle hypertrophy in response to stress
GO_2000377Biological processregulation of reactive oxygen species metabolic process
GO_0097150Biological processneuronal stem cell population maintenance
GO_0032869Biological processcellular response to insulin stimulus
GO_0070542Biological processresponse to fatty acid
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006974Biological processDNA damage response
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0009267Biological processcellular response to starvation
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0001678Biological processintracellular glucose homeostasis
GO_0046676Biological processnegative regulation of insulin secretion
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0071732Biological processcellular response to nitric oxide
GO_0034393Biological processpositive regulation of smooth muscle cell apoptotic process
GO_0070417Biological processcellular response to cold
GO_0032873Biological processnegative regulation of stress-activated MAPK cascade
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0045722Biological processpositive regulation of gluconeogenesis
GO_0034599Biological processcellular response to oxidative stress
GO_0008286Biological processinsulin receptor signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0060260Biological processregulation of transcription initiation by RNA polymerase II
GO_0010508Biological processpositive regulation of autophagy
GO_0001568Biological processblood vessel development
GO_0071455Biological processcellular response to hyperoxia
GO_0006915Biological processapoptotic process
GO_0001659Biological processtemperature homeostasis
GO_0006914Biological processautophagy
GO_0010467Biological processgene expression
GO_0006473Biological processprotein acetylation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0051721Molecular functionprotein phosphatase 2A binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003676Molecular functionnucleic acid binding
GO_0003682Molecular functionchromatin binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008013Molecular functionbeta-catenin binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFOXO1
Protein nameAlternative protein FOXO1
Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)
SynonymsFKHR
FOXO1A
DescriptionFUNCTION: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress . Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' . Activity suppressed by insulin . Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 . Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 . Promotes neural cell death . Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner . Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes . Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis . .

AccessionsENST00000379561.6
Q12778
L8E9Y8