TLE6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TLE6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TLE6 at tissue level.

III. Associated gene sets

GO_0040019Biological processpositive regulation of embryonic development
GO_0051646Biological processmitochondrion localization
GO_0060136Biological processembryonic process involved in female pregnancy
GO_0051643Biological processendoplasmic reticulum localization
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007015Biological processactin filament organization
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0051302Biological processregulation of cell division
GO_0051293Biological processestablishment of spindle localization
GO_0106333Cellular componentsubcortical maternal complex
GO_0032991Cellular componentprotein-containing complex
GO_0005938Cellular componentcell cortex
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTLE6
Protein nameTLE family member 6, subcortical maternal complex member (Transducin-like enhancer of split 6 (E(Sp1) homolog, Drosophila), isoform CRA_a)
TLE6 protein
Transducin-like enhancer protein 6
TLE family member 6, subcortical maternal complex member
SynonymshCG_23626
DescriptionFUNCTION: Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (By similarity). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity). .; FUNCTION: [Isoform 1]: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics . Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). .

AccessionsENST00000453329.5
ENST00000452088.5 [Q9H808-2]
C9J532
K7ENW8
Q6PJM9
ENST00000482627.1
ENST00000246112.9 [Q9H808-1]
Q9H808