Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| lung | 19 studies | 32% ± 13% | |
| brain | 17 studies | 32% ± 18% | |
| peripheral blood | 9 studies | 26% ± 12% | |
| eye | 9 studies | 28% ± 13% | |
| intestine | 8 studies | 29% ± 12% | |
| kidney | 6 studies | 23% ± 7% | |
| heart | 5 studies | 23% ± 4% | |
| uterus | 5 studies | 35% ± 13% | |
| adipose | 5 studies | 22% ± 4% | |
| liver | 5 studies | 29% ± 16% | |
| placenta | 4 studies | 37% ± 12% | |
| breast | 4 studies | 25% ± 3% | |
| pancreas | 3 studies | 32% ± 12% | |
| skin | 3 studies | 21% ± 3% | |
| prostate | 3 studies | 25% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 20312.37 | 578 / 578 | 100% | 138.75 | 1153 / 1155 |
| brain | 100% | 12368.98 | 2636 / 2642 | 100% | 119.51 | 704 / 705 |
| intestine | 100% | 17573.81 | 966 / 966 | 100% | 154.27 | 525 / 527 |
| breast | 100% | 19100.40 | 459 / 459 | 100% | 161.09 | 1113 / 1118 |
| esophagus | 100% | 14428.51 | 1445 / 1445 | 99% | 100.56 | 182 / 183 |
| stomach | 100% | 10936.59 | 359 / 359 | 99% | 137.58 | 284 / 286 |
| prostate | 100% | 18489.73 | 245 / 245 | 99% | 117.09 | 498 / 502 |
| skin | 100% | 17778.41 | 1809 / 1809 | 99% | 276.72 | 468 / 472 |
| thymus | 100% | 19855.97 | 653 / 653 | 99% | 169.62 | 598 / 605 |
| bladder | 100% | 16362.14 | 21 / 21 | 99% | 126.37 | 497 / 504 |
| ovary | 100% | 22510.56 | 180 / 180 | 99% | 84.41 | 424 / 430 |
| uterus | 100% | 22180.80 | 170 / 170 | 98% | 107.55 | 449 / 459 |
| pancreas | 98% | 7579.05 | 323 / 328 | 99% | 128.67 | 176 / 178 |
| kidney | 100% | 10243.82 | 89 / 89 | 93% | 81.98 | 840 / 901 |
| liver | 100% | 6807.69 | 226 / 226 | 90% | 55.21 | 367 / 406 |
| adrenal gland | 100% | 18346.12 | 258 / 258 | 89% | 68.23 | 205 / 230 |
| adipose | 100% | 17825.38 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 23158.10 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 14241.23 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 98.39 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 33.97 | 1 / 1 |
| heart | 99% | 10149.97 | 855 / 861 | 0% | 0 | 0 / 0 |
| muscle | 99% | 6746.27 | 795 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 50.45 | 28 / 29 |
| eye | 0% | 0 | 0 / 0 | 95% | 144.25 | 76 / 80 |
| peripheral blood | 78% | 5531.06 | 726 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002052 | Biological process | positive regulation of neuroblast proliferation |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0060789 | Biological process | hair follicle placode formation |
| GO_0001658 | Biological process | branching involved in ureteric bud morphogenesis |
| GO_1903377 | Biological process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| GO_0022009 | Biological process | central nervous system vasculogenesis |
| GO_0072033 | Biological process | renal vesicle formation |
| GO_0002062 | Biological process | chondrocyte differentiation |
| GO_0042733 | Biological process | embryonic digit morphogenesis |
| GO_0060441 | Biological process | epithelial tube branching involved in lung morphogenesis |
| GO_0021819 | Biological process | layer formation in cerebral cortex |
| GO_0001764 | Biological process | neuron migration |
| GO_0072054 | Biological process | renal outer medulla development |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0035115 | Biological process | embryonic forelimb morphogenesis |
| GO_0032331 | Biological process | negative regulation of chondrocyte differentiation |
| GO_0048599 | Biological process | oocyte development |
| GO_0002053 | Biological process | positive regulation of mesenchymal cell proliferation |
| GO_0060769 | Biological process | positive regulation of epithelial cell proliferation involved in prostate gland development |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0035995 | Biological process | detection of muscle stretch |
| GO_0035050 | Biological process | embryonic heart tube development |
| GO_0090425 | Biological process | acinar cell differentiation |
| GO_0097091 | Biological process | synaptic vesicle clustering |
| GO_0002089 | Biological process | lens morphogenesis in camera-type eye |
| GO_0050767 | Biological process | regulation of neurogenesis |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0036023 | Biological process | embryonic skeletal limb joint morphogenesis |
| GO_0007398 | Biological process | ectoderm development |
| GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO_1990403 | Biological process | embryonic brain development |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0072089 | Biological process | stem cell proliferation |
| GO_1904888 | Biological process | cranial skeletal system development |
| GO_0031641 | Biological process | regulation of myelination |
| GO_0097190 | Biological process | apoptotic signaling pathway |
| GO_0003340 | Biological process | negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0009948 | Biological process | anterior/posterior axis specification |
| GO_0009954 | Biological process | proximal/distal pattern formation |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0003266 | Biological process | regulation of secondary heart field cardioblast proliferation |
| GO_0000209 | Biological process | protein polyubiquitination |
| GO_0070602 | Biological process | regulation of centromeric sister chromatid cohesion |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_1901331 | Biological process | positive regulation of odontoblast differentiation |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0042129 | Biological process | regulation of T cell proliferation |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0045976 | Biological process | negative regulation of mitotic cell cycle, embryonic |
| GO_0035315 | Biological process | hair cell differentiation |
| GO_2000008 | Biological process | regulation of protein localization to cell surface |
| GO_0007155 | Biological process | cell adhesion |
| GO_0061047 | Biological process | positive regulation of branching involved in lung morphogenesis |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_0003338 | Biological process | metanephros morphogenesis |
| GO_2000288 | Biological process | positive regulation of myoblast proliferation |
| GO_0031396 | Biological process | regulation of protein ubiquitination |
| GO_0045765 | Biological process | regulation of angiogenesis |
| GO_0044338 | Biological process | canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation |
| GO_0048660 | Biological process | regulation of smooth muscle cell proliferation |
| GO_0033077 | Biological process | T cell differentiation in thymus |
| GO_0051450 | Biological process | myoblast proliferation |
| GO_0051963 | Biological process | regulation of synapse assembly |
| GO_0051884 | Biological process | regulation of timing of anagen |
| GO_0060767 | Biological process | epithelial cell proliferation involved in prostate gland development |
| GO_0035112 | Biological process | genitalia morphogenesis |
| GO_0045453 | Biological process | bone resorption |
| GO_0036520 | Biological process | astrocyte-dopaminergic neuron signaling |
| GO_1990138 | Biological process | neuron projection extension |
| GO_0072182 | Biological process | regulation of nephron tubule epithelial cell differentiation |
| GO_2000017 | Biological process | positive regulation of determination of dorsal identity |
| GO_0060484 | Biological process | lung-associated mesenchyme development |
| GO_0061550 | Biological process | cranial ganglion development |
| GO_0048617 | Biological process | embryonic foregut morphogenesis |
| GO_0071681 | Biological process | cellular response to indole-3-methanol |
| GO_0008543 | Biological process | fibroblast growth factor receptor signaling pathway |
| GO_0007405 | Biological process | neuroblast proliferation |
| GO_0032355 | Biological process | response to estradiol |
| GO_0060856 | Biological process | establishment of blood-brain barrier |
| GO_0048715 | Biological process | negative regulation of oligodendrocyte differentiation |
| GO_0090279 | Biological process | regulation of calcium ion import |
| GO_0060742 | Biological process | epithelial cell differentiation involved in prostate gland development |
| GO_0072079 | Biological process | nephron tubule formation |
| GO_0001708 | Biological process | cell fate specification |
| GO_0031016 | Biological process | pancreas development |
| GO_0007403 | Biological process | glial cell fate determination |
| GO_0030316 | Biological process | osteoclast differentiation |
| GO_0001840 | Biological process | neural plate development |
| GO_0072497 | Biological process | mesenchymal stem cell differentiation |
| GO_0031069 | Biological process | hair follicle morphogenesis |
| GO_0072053 | Biological process | renal inner medulla development |
| GO_0071363 | Biological process | cellular response to growth factor stimulus |
| GO_0048643 | Biological process | positive regulation of skeletal muscle tissue development |
| GO_0009950 | Biological process | dorsal/ventral axis specification |
| GO_0030997 | Biological process | regulation of centriole-centriole cohesion |
| GO_0060440 | Biological process | trachea formation |
| GO_0061549 | Biological process | sympathetic ganglion development |
| GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0061154 | Biological process | endothelial tube morphogenesis |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0019827 | Biological process | stem cell population maintenance |
| GO_0048538 | Biological process | thymus development |
| GO_0000578 | Biological process | embryonic axis specification |
| GO_0060916 | Biological process | mesenchymal cell proliferation involved in lung development |
| GO_0060066 | Biological process | oviduct development |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0050808 | Biological process | synapse organization |
| GO_0048469 | Biological process | cell maturation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0060487 | Biological process | lung epithelial cell differentiation |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0021854 | Biological process | hypothalamus development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0001702 | Biological process | gastrulation with mouth forming second |
| GO_0060492 | Biological process | lung induction |
| GO_0010909 | Biological process | positive regulation of heparan sulfate proteoglycan biosynthetic process |
| GO_0045671 | Biological process | negative regulation of osteoclast differentiation |
| GO_0001837 | Biological process | epithelial to mesenchymal transition |
| GO_0034333 | Biological process | adherens junction assembly |
| GO_1990963 | Biological process | establishment of blood-retinal barrier |
| GO_1904948 | Biological process | midbrain dopaminergic neuron differentiation |
| GO_0045603 | Biological process | positive regulation of endothelial cell differentiation |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0048145 | Biological process | regulation of fibroblast proliferation |
| GO_0061198 | Biological process | fungiform papilla formation |
| GO_2000648 | Biological process | positive regulation of stem cell proliferation |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0034394 | Biological process | protein localization to cell surface |
| GO_0035116 | Biological process | embryonic hindlimb morphogenesis |
| GO_0043525 | Biological process | positive regulation of neuron apoptotic process |
| GO_0032968 | Biological process | positive regulation of transcription elongation by RNA polymerase II |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0033234 | Biological process | negative regulation of protein sumoylation |
| GO_0001711 | Biological process | endodermal cell fate commitment |
| GO_0045743 | Biological process | positive regulation of fibroblast growth factor receptor signaling pathway |
| GO_0030539 | Biological process | male genitalia development |
| GO_0048664 | Biological process | neuron fate determination |
| GO_0051145 | Biological process | smooth muscle cell differentiation |
| GO_1990791 | Biological process | dorsal root ganglion development |
| GO_0048709 | Biological process | oligodendrocyte differentiation |
| GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
| GO_0030902 | Biological process | hindbrain development |
| GO_0032212 | Biological process | positive regulation of telomere maintenance via telomerase |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0048489 | Biological process | synaptic vesicle transport |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0032993 | Cellular component | protein-DNA complex |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0030018 | Cellular component | Z disc |
| GO_0071944 | Cellular component | cell periphery |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0005923 | Cellular component | bicellular tight junction |
| GO_0099092 | Cellular component | postsynaptic density, intracellular component |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0000922 | Cellular component | spindle pole |
| GO_0005916 | Cellular component | fascia adherens |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016600 | Cellular component | flotillin complex |
| GO_0030877 | Cellular component | beta-catenin destruction complex |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_1990711 | Cellular component | beta-catenin-ICAT complex |
| GO_0005912 | Cellular component | adherens junction |
| GO_0070369 | Cellular component | beta-catenin-TCF7L2 complex |
| GO_1990909 | Cellular component | Wnt signalosome |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0031528 | Cellular component | microvillus membrane |
| GO_0005813 | Cellular component | centrosome |
| GO_0000791 | Cellular component | euchromatin |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0034750 | Cellular component | Scrib-APC-beta-catenin complex |
| GO_0016328 | Cellular component | lateral plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_1990907 | Cellular component | beta-catenin-TCF complex |
| GO_0045177 | Cellular component | apical part of cell |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016342 | Cellular component | catenin complex |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0005829 | Cellular component | cytosol |
| GO_0045202 | Cellular component | synapse |
| GO_0005938 | Cellular component | cell cortex |
| GO_0030054 | Cellular component | cell junction |
| GO_0016327 | Cellular component | apicolateral plasma membrane |
| GO_0098831 | Cellular component | presynaptic active zone cytoplasmic component |
| GO_0045294 | Molecular function | alpha-catenin binding |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0001222 | Molecular function | transcription corepressor binding |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0019900 | Molecular function | kinase binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0001221 | Molecular function | transcription coregulator binding |
| GO_0046332 | Molecular function | SMAD binding |
| GO_0030331 | Molecular function | nuclear estrogen receptor binding |
| GO_0044325 | Molecular function | transmembrane transporter binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0016922 | Molecular function | nuclear receptor binding |
| GO_0019903 | Molecular function | protein phosphatase binding |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0070411 | Molecular function | I-SMAD binding |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0097718 | Molecular function | disordered domain specific binding |
| Gene name | CTNNB1 |
| Protein name | Cadherin-associated protein Catenin beta-1 (Beta-catenin) Catenin beta 1 |
| Synonyms | CTNNB PRO2286 OK/SW-cl.35 |
| Description | FUNCTION: Key downstream component of the canonical Wnt signaling pathway . In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome . In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes . Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion . Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization . Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 . Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML . Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). . |
| Accessions | ENST00000646116.1 ENST00000647413.1 ENST00000645276.1 ENST00000646381.1 ENST00000643297.1 A0A2R8Y7Z0 ENST00000645493.1 ENST00000646369.1 ENST00000646174.1 ENST00000645927.1 A0A2R8YCH5 ENST00000396183.7 ENST00000644906.1 ENST00000643541.1 ENST00000646725.1 ENST00000645900.1 ENST00000642992.1 ENST00000642836.1 ENST00000644867.1 A0A2R8Y5A3 ENST00000647264.1 ENST00000644138.1 ENST00000644524.1 A0A2R8YG06 ENST00000433400.6 B5BU28 ENST00000453024.6 B4DGU4 ENST00000349496.11 ENST00000431914.6 ENST00000426215.5 ENST00000642248.1 ENST00000643031.1 A0A2R8Y5Z1 ENST00000643992.1 ENST00000645210.1 ENST00000642426.1 ENST00000646074.1 A0A2R8Y6G0 ENST00000396185.8 G9GAG7 ENST00000645982.1 ENST00000642315.1 ENST00000645320.1 C9IZ65 A0A2R8Y804 A0A2R8Y543 A0A2R8Y5C3 ENST00000644678.1 ENST00000647390.1 ENST00000471014.2 ENST00000644873.1 ENST00000450969.6 ENST00000643977.1 A0A2R8Y815 ENST00000642886.1 ENST00000642986.1 P35222 ENST00000441708.2 A0A2R8Y750 ENST00000405570.6 |
