RUVBL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0006281Biological processDNA repair
GO_0045995Biological processregulation of embryonic development
GO_2000779Biological processregulation of double-strand break repair
GO_0034644Biological processcellular response to UV
GO_0071169Biological processestablishment of protein localization to chromatin
GO_0045739Biological processpositive regulation of DNA repair
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006282Biological processregulation of DNA repair
GO_1904874Biological processpositive regulation of telomerase RNA localization to Cajal body
GO_0071392Biological processcellular response to estradiol stimulus
GO_0060382Biological processregulation of DNA strand elongation
GO_1904507Biological processpositive regulation of telomere maintenance in response to DNA damage
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0006338Biological processchromatin remodeling
GO_0006457Biological processprotein folding
GO_0042981Biological processregulation of apoptotic process
GO_0000492Biological processbox C/D snoRNP assembly
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0050821Biological processprotein stabilization
GO_0006355Biological processregulation of DNA-templated transcription
GO_0000723Biological processtelomere maintenance
GO_0033044Biological processregulation of chromosome organization
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0006310Biological processDNA recombination
GO_0006275Biological processregulation of DNA replication
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000812Cellular componentSwr1 complex
GO_0071339Cellular componentMLL1 complex
GO_0000786Cellular componentnucleosome
GO_1990062Cellular componentRPAP3/R2TP/prefoldin-like complex
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0000791Cellular componenteuchromatin
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0016363Cellular componentnuclear matrix
GO_0120293Cellular componentdynein axonemal particle
GO_0101031Cellular componentprotein folding chaperone complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0097255Cellular componentR2TP complex
GO_1990904Cellular componentribonucleoprotein complex
GO_0031011Cellular componentIno80 complex
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0017025Molecular functionTBP-class protein binding
GO_0043531Molecular functionADP binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140585Molecular functionpromoter-enhancer loop anchoring activity
GO_0001094Molecular functionTFIID-class transcription factor complex binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0042802Molecular functionidentical protein binding
GO_0008013Molecular functionbeta-catenin binding
GO_0051082Molecular functionunfolded protein binding
GO_0003678Molecular functionDNA helicase activity
GO_0005524Molecular functionATP binding
GO_0051117Molecular functionATPase binding
GO_0031490Molecular functionchromatin DNA binding
GO_0000979Molecular functionRNA polymerase II core promoter sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameRUVBL2
Protein nameRuvB-like helicase (EC 3.6.4.12)
RuvB like AAA ATPase 2 (RuvB-like 2 (E. coli), isoform CRA_c)
RuvB like AAA ATPase 2 (RuvB-like 2 (E. coli), isoform CRA_b)
RuvB like AAA ATPase 2
RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)
SynonymsTIP49B
hCG_16214
INO80J
CGI-46
TIP48
DescriptionFUNCTION: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity . Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A . This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription . This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair . The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 . NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage . Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome . Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding . Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex . May also inhibit the transcriptional activity of ATF2 . Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes . May play a role in regulating the composition of the U5 snRNP complex . .

FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. .

FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. .

FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. .

FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. .

AccessionsQ9Y230
ENST00000595090.6 [Q9Y230-1]
ENST00000593570.5
ENST00000596247.5
B3KNL2
X6R2L4
M0R0Z0
ENST00000596837.5
M0QXI6
M0QYD8
ENST00000595811.5
ENST00000601968.5
ENST00000627972.1
ENST00000221413.10
M0QXZ7
M0R0Y3