KREMEN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007154Biological processcell communication
GO_0006915Biological processapoptotic process
GO_0030279Biological processnegative regulation of ossification
GO_0060173Biological processlimb development
GO_0007275Biological processmulticellular organism development
GO_0048681Biological processnegative regulation of axon regeneration
GO_0016055Biological processWnt signaling pathway
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0043025Cellular componentneuronal cell body
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKREMEN1
Protein nameKringle containing transmembrane protein 1
Kremen protein 1 (Dickkopf receptor) (Kringle domain-containing transmembrane protein 1) (Kringle-containing protein marking the eye and the nose)
SynonymsKREMEN
KRM1
DescriptionFUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification. .

AccessionsQ96MU8
ENST00000407188.5 [Q96MU8-1]
ENST00000453585.1
ENST00000400335.9 [Q96MU8-3]
H7BZ87
ENST00000327813.9 [Q96MU8-2]