HECW1 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	14 studies	51% ± 20%	Explore
glutamatergic neuron	13 studies	68% ± 25%	Explore
GABAergic neuron	10 studies	54% ± 18%	Explore
interneuron	6 studies	63% ± 15%	Explore
neuron	5 studies	46% ± 18%	Explore
retina horizontal cell	5 studies	66% ± 26%	Explore
endothelial cell	3 studies	51% ± 23%	Explore
GABAergic interneuron	3 studies	48% ± 17%	Explore
granule cell	3 studies	45% ± 8%	Explore

Name	Number of supported studies	Average coverage
brain	15 studies	43% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	97%	1341.03	2568 / 2642	70%	3.37	495 / 705
prostate	84%	252.82	207 / 245	18%	0.63	88 / 502
kidney	88%	626.64	78 / 89	12%	0.29	106 / 901
bladder	52%	70.38	11 / 21	9%	0.25	45 / 504
thymus	50%	66.87	328 / 653	2%	0.08	15 / 605
skin	37%	72.88	678 / 1809	7%	0.16	32 / 472
ovary	36%	65.98	64 / 180	8%	0.14	35 / 430
muscle	42%	63.73	340 / 803	0%	0	0 / 0
esophagus	3%	2.67	41 / 1445	21%	0.41	38 / 183
adipose	21%	24.54	257 / 1204	0%	0	0 / 0
lung	5%	5.40	29 / 578	11%	0.22	127 / 1155
breast	14%	17.08	64 / 459	2%	0.03	17 / 1118
stomach	8%	9.84	28 / 359	7%	0.09	19 / 286
pancreas	0%	0	0 / 328	14%	0.25	25 / 178
intestine	6%	5.31	55 / 966	4%	0.08	23 / 527
uterus	5%	6.27	9 / 170	4%	0.09	20 / 459
adrenal gland	1%	2.67	3 / 258	3%	0.07	7 / 230
lymph node	0%	0	0 / 0	3%	0.39	1 / 29
blood vessel	3%	2.96	36 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	3%	0.04	2 / 80
liver	0%	0	0 / 226	2%	0.04	9 / 406
heart	0%	0.42	4 / 861	0%	0	0 / 0
peripheral blood	0%	0.25	3 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0016567	Biological process	protein ubiquitination
GO_2000650	Biological process	negative regulation of sodium ion transmembrane transporter activity
GO_0048814	Biological process	regulation of dendrite morphogenesis
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0005515	Molecular function	protein binding

Gene name	HECW1
Protein name	E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
Synonyms	NEDL1 KIAA0322
Description	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. .
Accessions	ENST00000453890.5 [Q76N89-2] ENST00000395891.7 [Q76N89-1] H7C3Q2 Q76N89 ENST00000429529.1

HECW1 report