TMEM64 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0051480Biological processregulation of cytosolic calcium ion concentration
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0045780Biological processpositive regulation of bone resorption
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0030316Biological processosteoclast differentiation
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane

IV. Literature review

[source]
Gene nameTMEM64
Protein nameTransmembrane protein 64
SynonymshCG_32991
DescriptionFUNCTION: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1. .

AccessionsB3KW24
ENST00000422900.1
ENST00000418210.2 [Q6YI46-4]
E5RIS8
H0Y6S7
ENST00000458549.7 [Q6YI46-1]
ENST00000521852.5
ENST00000519519.5 [Q6YI46-2]
Q6YI46