PRICKLE1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	14 studies	26% ± 8%	Explore
oligodendrocyte precursor cell	10 studies	31% ± 10%	Explore
glutamatergic neuron	9 studies	60% ± 24%	Explore
smooth muscle cell	7 studies	25% ± 9%	Explore
GABAergic neuron	7 studies	45% ± 23%	Explore
retinal ganglion cell	5 studies	35% ± 16%	Explore
type I pneumocyte	5 studies	23% ± 7%	Explore
cardiac muscle cell	5 studies	24% ± 4%	Explore
neuron	4 studies	24% ± 9%	Explore
endothelial cell	4 studies	35% ± 10%	Explore
granule cell	3 studies	36% ± 13%	Explore
adipocyte	3 studies	20% ± 1%	Explore
ON-bipolar cell	3 studies	31% ± 3%	Explore
interneuron	3 studies	55% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	36% ± 25%	Explore
adipose	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	665.37	457 / 459	94%	5.74	1053 / 1118
thymus	100%	781.15	651 / 653	92%	11.42	558 / 605
brain	92%	446.66	2420 / 2642	91%	3.74	641 / 705
ovary	100%	753.76	180 / 180	77%	3.19	331 / 430
lung	100%	638.51	576 / 578	66%	1.72	763 / 1155
kidney	97%	406.34	86 / 89	69%	3.74	621 / 901
uterus	100%	1088.19	170 / 170	52%	1.82	238 / 459
skin	94%	516.07	1705 / 1809	57%	1.77	271 / 472
prostate	96%	478.82	235 / 245	54%	0.96	270 / 502
bladder	100%	738.05	21 / 21	40%	1.20	204 / 504
esophagus	82%	467.07	1182 / 1445	57%	2.10	104 / 183
pancreas	42%	84.21	139 / 328	90%	3.41	161 / 178
adrenal gland	67%	142.40	173 / 258	45%	1.17	104 / 230
stomach	74%	204.63	267 / 359	37%	0.98	105 / 286
intestine	87%	379.65	837 / 966	22%	0.60	116 / 527
spleen	100%	1184.95	241 / 241	0%	0	0 / 0
adipose	99%	706.02	1197 / 1204	0%	0	0 / 0
heart	99%	553.68	849 / 861	0%	0	0 / 0
blood vessel	94%	363.98	1253 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	52%	1.37	15 / 29
tonsil	0%	0	0 / 0	49%	1.32	22 / 45
muscle	46%	108.44	372 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	46%	1.02	37 / 80
liver	8%	12.47	18 / 226	14%	0.62	58 / 406
peripheral blood	11%	18.86	101 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0060271	Biological process	cilium assembly
GO_2000691	Biological process	negative regulation of cardiac muscle cell myoblast differentiation
GO_0035904	Biological process	aorta development
GO_0003151	Biological process	outflow tract morphogenesis
GO_1905070	Biological process	anterior visceral endoderm cell migration
GO_0035880	Biological process	embryonic nail plate morphogenesis
GO_0070075	Biological process	tear secretion
GO_0061303	Biological process	cornea development in camera-type eye
GO_0003402	Biological process	planar cell polarity pathway involved in axis elongation
GO_0085029	Biological process	extracellular matrix assembly
GO_0051602	Biological process	response to electrical stimulus
GO_0061159	Biological process	establishment of bipolar cell polarity involved in cell morphogenesis
GO_0055013	Biological process	cardiac muscle cell development
GO_0090009	Biological process	primitive streak formation
GO_0032436	Biological process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0061865	Biological process	polarized secretion of basement membrane proteins in epithelium
GO_1990403	Biological process	embryonic brain development
GO_0035264	Biological process	multicellular organism growth
GO_0060976	Biological process	coronary vasculature development
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0007409	Biological process	axonogenesis
GO_0061326	Biological process	renal tubule development
GO_0071711	Biological process	basement membrane organization
GO_0090307	Biological process	mitotic spindle assembly
GO_0060485	Biological process	mesenchyme development
GO_0016192	Biological process	vesicle-mediated transport
GO_0036342	Biological process	post-anal tail morphogenesis
GO_0030282	Biological process	bone mineralization
GO_0006606	Biological process	protein import into nucleus
GO_0001843	Biological process	neural tube closure
GO_0006915	Biological process	apoptotic process
GO_0007173	Biological process	epidermal growth factor receptor signaling pathway
GO_0060071	Biological process	Wnt signaling pathway, planar cell polarity pathway
GO_0010467	Biological process	gene expression
GO_0031398	Biological process	positive regulation of protein ubiquitination
GO_1990138	Biological process	neuron projection extension
GO_0001894	Biological process	tissue homeostasis
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0120181	Biological process	focal adhesion disassembly
GO_0016358	Biological process	dendrite development
GO_0098609	Biological process	cell-cell adhesion
GO_0060325	Biological process	face morphogenesis
GO_0061029	Biological process	eyelid development in camera-type eye
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0030705	Biological process	cytoskeleton-dependent intracellular transport
GO_0000502	Cellular component	proteasome complex
GO_0005829	Cellular component	cytosol
GO_0031965	Cellular component	nuclear membrane
GO_0031254	Cellular component	cell trailing edge
GO_0005634	Cellular component	nucleus
GO_0044877	Molecular function	protein-containing complex binding
GO_0008270	Molecular function	zinc ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PRICKLE1
Protein name	Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1) Prickle planar cell polarity protein 1
Synonyms	RILP
Description	FUNCTION: Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. .
Accessions	ENST00000551050.6 ENST00000640801.1 ENST00000445766.7 ENST00000455697.6 ENST00000639566.1 ENST00000552240.6 Q96MT3 F8VUG8 ENST00000547113.1 F8W1J1 ENST00000640055.1 ENST00000548696.6 ENST00000640646.1 ENST00000345127.9 A0A1W2PPC7 ENST00000640132.1 F8W1Q8 ENST00000639958.1 ENST00000639589.1 ENST00000552108.6

PRICKLE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review