LRP5 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	8 studies	26% ± 12%	Explore
endothelial cell of lymphatic vessel	8 studies	25% ± 9%	Explore
adipocyte	7 studies	19% ± 2%	Explore
type I pneumocyte	6 studies	21% ± 4%	Explore
epithelial cell	5 studies	27% ± 8%	Explore
goblet cell	5 studies	28% ± 10%	Explore
ciliated cell	4 studies	20% ± 3%	Explore
hepatocyte	4 studies	46% ± 17%	Explore
basal cell	4 studies	23% ± 6%	Explore
astrocyte	4 studies	22% ± 6%	Explore
club cell	3 studies	24% ± 7%	Explore
brush cell	3 studies	31% ± 7%	Explore
mucus secreting cell	3 studies	28% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4637.65	1445 / 1445	100%	119.79	183 / 183
intestine	100%	6004.85	966 / 966	99%	101.89	523 / 527
prostate	100%	4909.09	245 / 245	99%	63.06	498 / 502
ovary	100%	5457.68	180 / 180	99%	67.91	426 / 430
liver	100%	8698.12	226 / 226	99%	79.37	402 / 406
pancreas	100%	3291.73	328 / 328	99%	76.68	176 / 178
stomach	100%	4537.69	359 / 359	99%	105.44	282 / 286
lung	99%	4725.30	575 / 578	99%	73.36	1140 / 1155
thymus	100%	6687.86	653 / 653	98%	55.64	593 / 605
bladder	100%	5093.71	21 / 21	97%	71.58	490 / 504
breast	100%	7661.89	459 / 459	97%	55.92	1079 / 1118
kidney	100%	3975.98	89 / 89	96%	47.87	862 / 901
uterus	100%	6409.41	170 / 170	95%	52.35	438 / 459
skin	99%	3295.59	1795 / 1809	68%	27.46	322 / 472
adrenal gland	100%	5777.47	258 / 258	57%	16.51	130 / 230
brain	31%	370.89	818 / 2642	93%	30.40	653 / 705
adipose	100%	6105.32	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8958.75	1335 / 1335	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	59.01	1 / 1
heart	99%	4080.47	851 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	35.44	44 / 45
eye	0%	0	0 / 0	98%	36.29	78 / 80
spleen	83%	1396.16	200 / 241	0%	0	0 / 0
muscle	81%	1119.94	650 / 803	0%	0	0 / 0
peripheral blood	18%	442.33	165 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	17%	3.77	5 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0033687	Biological process	osteoblast proliferation
GO_0060856	Biological process	establishment of blood-brain barrier
GO_0060349	Biological process	bone morphogenesis
GO_0006897	Biological process	endocytosis
GO_0043434	Biological process	response to peptide hormone
GO_0033690	Biological process	positive regulation of osteoblast proliferation
GO_1990963	Biological process	establishment of blood-retinal barrier
GO_0060444	Biological process	branching involved in mammary gland duct morphogenesis
GO_0061304	Biological process	retinal blood vessel morphogenesis
GO_0048539	Biological process	bone marrow development
GO_0008217	Biological process	regulation of blood pressure
GO_0006007	Biological process	glucose catabolic process
GO_0008203	Biological process	cholesterol metabolic process
GO_0042733	Biological process	embryonic digit morphogenesis
GO_0110135	Biological process	Norrin signaling pathway
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0042632	Biological process	cholesterol homeostasis
GO_0002053	Biological process	positive regulation of mesenchymal cell proliferation
GO_0008078	Biological process	mesodermal cell migration
GO_0042981	Biological process	regulation of apoptotic process
GO_0046849	Biological process	bone remodeling
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0060042	Biological process	retina morphogenesis in camera-type eye
GO_0061178	Biological process	regulation of insulin secretion involved in cellular response to glucose stimulus
GO_1902262	Biological process	apoptotic process involved in blood vessel morphogenesis
GO_0045600	Biological process	positive regulation of fat cell differentiation
GO_0042074	Biological process	cell migration involved in gastrulation
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0060764	Biological process	cell-cell signaling involved in mammary gland development
GO_0009952	Biological process	anterior/posterior pattern specification
GO_0060612	Biological process	adipose tissue development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0060033	Biological process	anatomical structure regression
GO_0006865	Biological process	amino acid transport
GO_0010467	Biological process	gene expression
GO_0035426	Biological process	extracellular matrix-cell signaling
GO_0098609	Biological process	cell-cell adhesion
GO_0002076	Biological process	osteoblast development
GO_0071901	Biological process	negative regulation of protein serine/threonine kinase activity
GO_0007399	Biological process	nervous system development
GO_0045840	Biological process	positive regulation of mitotic nuclear division
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0001702	Biological process	gastrulation with mouth forming second
GO_0035019	Biological process	somatic stem cell population maintenance
GO_1990851	Cellular component	Wnt-Frizzled-LRP5/6 complex
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_1990909	Cellular component	Wnt signalosome
GO_0017147	Molecular function	Wnt-protein binding
GO_0015026	Molecular function	coreceptor activity
GO_0042813	Molecular function	Wnt receptor activity
GO_0019534	Molecular function	toxin transmembrane transporter activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LRP5
Protein name	Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7) LDL receptor related protein 5 Low-density lipoprotein receptor-related protein 5
Synonyms	LR3 LRP7
Description	FUNCTION: Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins . Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration . In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass . Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs . Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development . Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (By similarity). .
Accessions	H0YE98 ENST00000529993.5 ENST00000529702.1 A0A1P8NQD1 A0A1P8NQD0 A0A1P8NQE2 O75197 E9PHY1 ENST00000294304.12

LRP5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review