DVL1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DVL1 at tissue level.

III. Associated gene sets

GO_0071340Biological processskeletal muscle acetylcholine-gated channel clustering
GO_0003151Biological processoutflow tract morphogenesis
GO_0048668Biological processcollateral sprouting
GO_0031122Biological processcytoplasmic microtubule organization
GO_0010976Biological processpositive regulation of neuron projection development
GO_0001947Biological processheart looping
GO_0048813Biological processdendrite morphogenesis
GO_0007269Biological processneurotransmitter secretion
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0032880Biological processregulation of protein localization
GO_0090103Biological processcochlea morphogenesis
GO_0016079Biological processsynaptic vesicle exocytosis
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0007528Biological processneuromuscular junction development
GO_0060070Biological processcanonical Wnt signaling pathway
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_0043113Biological processreceptor clustering
GO_0090179Biological processplanar cell polarity pathway involved in neural tube closure
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0150012Biological processpositive regulation of neuron projection arborization
GO_0035556Biological processintracellular signal transduction
GO_0022007Biological processconvergent extension involved in neural plate elongation
GO_0035372Biological processprotein localization to microtubule
GO_0034504Biological processprotein localization to nucleus
GO_0050821Biological processprotein stabilization
GO_0006355Biological processregulation of DNA-templated transcription
GO_0099054Biological processpresynapse assembly
GO_0048675Biological processaxon extension
GO_0060071Biological processWnt signaling pathway, planar cell polarity pathway
GO_0035567Biological processnon-canonical Wnt signaling pathway
GO_1905386Biological processpositive regulation of protein localization to presynapse
GO_0060134Biological processprepulse inhibition
GO_0035176Biological processsocial behavior
GO_0021915Biological processneural tube development
GO_0050808Biological processsynapse organization
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0007411Biological processaxon guidance
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0099175Biological processregulation of postsynapse organization
GO_0060997Biological processdendritic spine morphogenesis
GO_0098978Cellular componentglutamatergic synapse
GO_0098992Cellular componentneuronal dense core vesicle
GO_0098793Cellular componentpresynapse
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005874Cellular componentmicrotubule
GO_0031410Cellular componentcytoplasmic vesicle
GO_0043197Cellular componentdendritic spine
GO_0030136Cellular componentclathrin-coated vesicle
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0016328Cellular componentlateral plasma membrane
GO_1990909Cellular componentWnt signalosome
GO_0019899Molecular functionenzyme binding
GO_0019901Molecular functionprotein kinase binding
GO_0005109Molecular functionfrizzled binding
GO_0042802Molecular functionidentical protein binding
GO_0008013Molecular functionbeta-catenin binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDVL1
Protein nameDVL1 protein
Dishevelled segment polarity protein 1
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Putative segment polarity protein dishevelled homolog DVL1P1 (DSH homolog 1-like) (Segment polarity protein dishevelled homolog DVL-1-like) (Dishevelled-1-like)
Dishevelled, dsh homolog 1 (Drosophila)
SynonymsDVL1L1
DVL1P1
DVL
DescriptionFUNCTION: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

FUNCTION: May play a role in the signal transduction pathway mediated by multiple Wnt genes.

AccessionsENST00000632445.1
Q6PJD6
ENST00000378888.10 [O14640-1]
P54792
ENST00000378891.9 [O14640-2]
O14640
A0A0J9YYK1
ENST00000631679.1
Q86TH3
A0A0J9YWZ5