LRP6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	18 studies	32% ± 14%	Explore
oligodendrocyte precursor cell	10 studies	37% ± 17%	Explore
astrocyte	9 studies	38% ± 17%	Explore
oligodendrocyte	8 studies	37% ± 17%	Explore
type I pneumocyte	6 studies	27% ± 11%	Explore
GABAergic neuron	6 studies	34% ± 17%	Explore
epithelial cell	6 studies	31% ± 12%	Explore
type II pneumocyte	6 studies	29% ± 10%	Explore
fibroblast	6 studies	22% ± 7%	Explore
interneuron	5 studies	41% ± 22%	Explore
neuron	5 studies	40% ± 17%	Explore
endothelial cell of artery	4 studies	30% ± 18%	Explore
glutamatergic neuron	4 studies	44% ± 20%	Explore
retinal pigment epithelial cell	4 studies	31% ± 9%	Explore
club cell	4 studies	27% ± 10%	Explore
endothelial cell of lymphatic vessel	4 studies	28% ± 4%	Explore
glial cell	3 studies	28% ± 7%	Explore
granule cell	3 studies	20% ± 1%	Explore
microglial cell	3 studies	23% ± 5%	Explore
pericyte	3 studies	25% ± 7%	Explore
ciliated cell	3 studies	22% ± 7%	Explore
Mueller cell	3 studies	31% ± 17%	Explore
hepatocyte	3 studies	61% ± 15%	Explore
connective tissue cell	3 studies	18% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	8 studies	38% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	3357.98	245 / 245	100%	15.28	500 / 502
brain	100%	2001.92	2638 / 2642	100%	19.68	702 / 705
pancreas	100%	2310.40	328 / 328	99%	12.17	176 / 178
esophagus	100%	2302.42	1444 / 1445	99%	19.35	181 / 183
breast	100%	3832.70	459 / 459	99%	21.36	1104 / 1118
lung	100%	3818.27	578 / 578	99%	15.44	1140 / 1155
intestine	100%	3266.37	966 / 966	98%	13.58	519 / 527
ovary	100%	4198.91	180 / 180	98%	16.37	423 / 430
stomach	100%	2316.59	359 / 359	98%	16.22	280 / 286
liver	100%	3409.07	226 / 226	98%	13.35	396 / 406
adrenal gland	100%	1702.69	258 / 258	97%	10.52	223 / 230
thymus	100%	3794.70	653 / 653	96%	12.62	583 / 605
skin	100%	2585.56	1807 / 1809	96%	18.43	452 / 472
kidney	100%	2201.79	89 / 89	95%	13.86	860 / 901
bladder	100%	2856.62	21 / 21	95%	10.25	479 / 504
uterus	100%	5687.93	170 / 170	92%	11.85	423 / 459
adipose	100%	2814.88	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3426.25	1335 / 1335	0%	0	0 / 0
muscle	100%	1816.60	803 / 803	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.40	1 / 1
heart	97%	1538.96	838 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	10.99	42 / 45
spleen	87%	783.34	210 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	76%	6.14	61 / 80
lymph node	0%	0	0 / 0	17%	0.72	5 / 29
peripheral blood	9%	86.77	82 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0072659	Biological process	protein localization to plasma membrane
GO_0006897	Biological process	endocytosis
GO_0043434	Biological process	response to peptide hormone
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_1904948	Biological process	midbrain dopaminergic neuron differentiation
GO_0055085	Biological process	transmembrane transport
GO_0034392	Biological process	negative regulation of smooth muscle cell apoptotic process
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0071542	Biological process	dopaminergic neuron differentiation
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0007268	Biological process	chemical synaptic transmission
GO_0071397	Biological process	cellular response to cholesterol
GO_0014029	Biological process	neural crest formation
GO_0014033	Biological process	neural crest cell differentiation
GO_0016055	Biological process	Wnt signaling pathway
GO_0098609	Biological process	cell-cell adhesion
GO_0007399	Biological process	nervous system development
GO_0045787	Biological process	positive regulation of cell cycle
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0071901	Biological process	negative regulation of protein serine/threonine kinase activity
GO_1990851	Cellular component	Wnt-Frizzled-LRP5/6 complex
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0005769	Cellular component	early endosome
GO_0031901	Cellular component	early endosome membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0043025	Cellular component	neuronal cell body
GO_0009986	Cellular component	cell surface
GO_0005783	Cellular component	endoplasmic reticulum
GO_0045202	Cellular component	synapse
GO_1990909	Cellular component	Wnt signalosome
GO_0005901	Cellular component	caveola
GO_0017147	Molecular function	Wnt-protein binding
GO_0015026	Molecular function	coreceptor activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0005109	Molecular function	frizzled binding
GO_0005102	Molecular function	signaling receptor binding
GO_0019210	Molecular function	kinase inhibitor activity
GO_0042802	Molecular function	identical protein binding
GO_0042813	Molecular function	Wnt receptor activity
GO_0019534	Molecular function	toxin transmembrane transporter activity
GO_0005041	Molecular function	low-density lipoprotein particle receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LRP6
Protein name	Low-density lipoprotein receptor-related protein 6 (LRP-6) Low-density lipoprotein receptor-related protein LDL receptor related protein 6 (Low-density lipoprotein receptor-related protein 6)
Synonyms
Description	FUNCTION: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). . FUNCTION: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. . FUNCTION: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. .
Accessions	ENST00000543091.1 ENST00000625211 O75581 H0YGH0 ENST00000626957 ENST00000535731.1 F5H7J9 ENST00000626698 F5H0Z3 ENST00000626182 B7ZLD0 ENST00000540527.5 H0YGW5 ENST00000538239.5 ENST00000261349.9 ENST00000628182.3

LRP6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review