I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 9 studies | 41% ± 24% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 9 studies | 41% ± 24% |
Insufficient scRNA-seq data for expression of WNT2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 1444.81 | 577 / 578 | 77% | 6.28 | 885 / 1155 |
| breast | 82% | 181.13 | 377 / 459 | 86% | 9.05 | 957 / 1118 |
| uterus | 89% | 632.22 | 151 / 170 | 54% | 4.74 | 246 / 459 |
| prostate | 98% | 775.69 | 241 / 245 | 44% | 3.50 | 220 / 502 |
| bladder | 38% | 97.24 | 8 / 21 | 65% | 5.98 | 330 / 504 |
| intestine | 20% | 18.29 | 192 / 966 | 79% | 6.94 | 414 / 527 |
| spleen | 98% | 199.03 | 237 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 44% | 42.68 | 638 / 1445 | 49% | 3.50 | 90 / 183 |
| skin | 65% | 90.31 | 1181 / 1809 | 27% | 1.56 | 128 / 472 |
| pancreas | 1% | 0.58 | 3 / 328 | 85% | 9.90 | 151 / 178 |
| stomach | 6% | 7.23 | 21 / 359 | 76% | 6.61 | 216 / 286 |
| adipose | 77% | 183.10 | 924 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 35% | 57.22 | 63 / 180 | 41% | 2.95 | 177 / 430 |
| brain | 41% | 44.78 | 1089 / 2642 | 11% | 0.78 | 79 / 705 |
| thymus | 37% | 22.95 | 242 / 653 | 13% | 2.09 | 78 / 605 |
| heart | 43% | 32.39 | 374 / 861 | 0% | 0 | 0 / 0 |
| liver | 36% | 25.36 | 82 / 226 | 2% | 0.16 | 10 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 38% | 2.14 | 11 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 38% | 3.15 | 17 / 45 |
| blood vessel | 35% | 30.44 | 471 / 1335 | 0% | 0 | 0 / 0 |
| kidney | 22% | 9.75 | 20 / 89 | 10% | 1.01 | 92 / 901 |
| peripheral blood | 8% | 8.44 | 71 / 929 | 0% | 0 | 0 / 0 |
| adrenal gland | 1% | 0.33 | 3 / 258 | 2% | 0.14 | 4 / 230 |
| muscle | 1% | 0.36 | 6 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0060492 | Biological process | lung induction |
| GO_0071300 | Biological process | cellular response to retinoic acid |
| GO_0071560 | Biological process | cellular response to transforming growth factor beta stimulus |
| GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
| GO_0060501 | Biological process | positive regulation of epithelial cell proliferation involved in lung morphogenesis |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_1904948 | Biological process | midbrain dopaminergic neuron differentiation |
| GO_0060045 | Biological process | positive regulation of cardiac muscle cell proliferation |
| GO_0050769 | Biological process | positive regulation of neurogenesis |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0060317 | Biological process | cardiac epithelial to mesenchymal transition |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0060038 | Biological process | cardiac muscle cell proliferation |
| GO_0002053 | Biological process | positive regulation of mesenchymal cell proliferation |
| GO_0030182 | Biological process | neuron differentiation |
| GO_0061180 | Biological process | mammary gland epithelium development |
| GO_0022008 | Biological process | neurogenesis |
| GO_0045165 | Biological process | cell fate commitment |
| GO_0033278 | Biological process | cell proliferation in midbrain |
| GO_0060716 | Biological process | labyrinthine layer blood vessel development |
| GO_0010463 | Biological process | mesenchymal cell proliferation |
| GO_0002088 | Biological process | lens development in camera-type eye |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0061072 | Biological process | iris morphogenesis |
| GO_0060502 | Biological process | epithelial cell proliferation involved in lung morphogenesis |
| GO_0055009 | Biological process | atrial cardiac muscle tissue morphogenesis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005737 | Cellular component | cytoplasm |
| GO_1990909 | Cellular component | Wnt signalosome |
| GO_0048018 | Molecular function | receptor ligand activity |
| GO_0005109 | Molecular function | frizzled binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | WNT2 |
| Protein name | Alternative protein WNT2 Protein Wnt Protein Wnt-2 (Int-1-like protein 1) (Int-1-related protein) (IRP) |
| Synonyms | IRP INT1L1 |
| Description | FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family . Functions as a upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). . FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. . FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. . FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. . |
| Accessions | C9JUI2 F8WDR1 ENST00000491214.1 P09544 ENST00000647844.1 ENST00000449446.5 ENST00000265441.8 A0A3B3ITC9 L8EA39 |
