RECK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001955Biological processblood vessel maturation
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_1904684Biological processnegative regulation of metalloendopeptidase activity
GO_0030198Biological processextracellular matrix organization
GO_0090210Biological processregulation of establishment of blood-brain barrier
GO_0035115Biological processembryonic forelimb morphogenesis
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0045765Biological processregulation of angiogenesis
GO_0002040Biological processsprouting angiogenesis
GO_1903053Biological processregulation of extracellular matrix organization
GO_0030336Biological processnegative regulation of cell migration
GO_0007566Biological processembryo implantation
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_1990909Cellular componentWnt signalosome
GO_0098552Cellular componentside of membrane
GO_0017147Molecular functionWnt-protein binding
GO_0015026Molecular functioncoreceptor activity
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0004867Molecular functionserine-type endopeptidase inhibitor activity
GO_0008191Molecular functionmetalloendopeptidase inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRECK
Protein nameReversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein)
RECK protein
SynonymsST15
DescriptionFUNCTION: Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) . Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 . ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex . Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity . Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) . .

AccessionsO95980
Q6P9E2
ENST00000377966.4