WNT3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of WNT3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WNT3 at tissue level.

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0009948Biological processanterior/posterior axis specification
GO_0048697Biological processpositive regulation of collateral sprouting in absence of injury
GO_1904948Biological processmidbrain dopaminergic neuron differentiation
GO_0010628Biological processpositive regulation of gene expression
GO_0007411Biological processaxon guidance
GO_0007276Biological processgamete generation
GO_0060174Biological processlimb bud formation
GO_2000739Biological processregulation of mesenchymal stem cell differentiation
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0035115Biological processembryonic forelimb morphogenesis
GO_0035116Biological processembryonic hindlimb morphogenesis
GO_0009950Biological processdorsal/ventral axis specification
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0044338Biological processcanonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
GO_0030182Biological processneuron differentiation
GO_0061180Biological processmammary gland epithelium development
GO_0045165Biological processcell fate commitment
GO_0001707Biological processmesoderm formation
GO_0060064Biological processSpemann organizer formation at the anterior end of the primitive streak
GO_0010467Biological processgene expression
GO_0000902Biological processcell morphogenesis
GO_0050767Biological processregulation of neurogenesis
GO_0060323Biological processhead morphogenesis
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0048843Biological processnegative regulation of axon extension involved in axon guidance
GO_0072089Biological processstem cell proliferation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0005796Cellular componentGolgi lumen
GO_0070062Cellular componentextracellular exosome
GO_0031012Cellular componentextracellular matrix
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_1990909Cellular componentWnt signalosome
GO_0019904Molecular functionprotein domain specific binding
GO_0048018Molecular functionreceptor ligand activity
GO_0005109Molecular functionfrizzled binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameWNT3
Protein nameWnt family member 3
Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog)
Protein Wnt
SynonymsINT4
DescriptionFUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family . Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development . .

FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. .

FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. .

AccessionsENST00000706485.1
A0A9L9PXJ3
ENST00000706495.1
ENST00000616347.2
P56703
A0A9L9PXI5
A0A9L9PXK4
ENST00000706484.1
ENST00000611547.1
ENST00000225512.6
ENST00000706483.1