I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 6 studies | 32% ± 12% | |
| GABAergic neuron | 4 studies | 32% ± 12% | |
| interneuron | 3 studies | 26% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 6 studies | 32% ± 12% | |
| GABAergic neuron | 4 studies | 32% ± 12% | |
| interneuron | 3 studies | 26% ± 9% |
Insufficient scRNA-seq data for expression of LYPD6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 95% | 367.24 | 20 / 21 | 83% | 8.84 | 417 / 504 |
| brain | 100% | 600.43 | 2635 / 2642 | 78% | 7.07 | 549 / 705 |
| intestine | 93% | 205.48 | 901 / 966 | 81% | 4.89 | 429 / 527 |
| stomach | 96% | 287.73 | 345 / 359 | 78% | 5.64 | 223 / 286 |
| pancreas | 95% | 177.19 | 311 / 328 | 79% | 4.97 | 140 / 178 |
| uterus | 90% | 290.25 | 153 / 170 | 79% | 6.52 | 363 / 459 |
| prostate | 81% | 135.00 | 199 / 245 | 82% | 4.73 | 413 / 502 |
| breast | 75% | 365.96 | 344 / 459 | 77% | 14.14 | 866 / 1118 |
| esophagus | 79% | 110.92 | 1144 / 1445 | 70% | 4.93 | 129 / 183 |
| ovary | 50% | 76.98 | 90 / 180 | 97% | 10.73 | 419 / 430 |
| skin | 54% | 156.32 | 980 / 1809 | 55% | 3.55 | 261 / 472 |
| ureter | 0% | 0 | 0 / 0 | 100% | 11.72 | 1 / 1 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 7.30 | 35 / 45 |
| lung | 21% | 29.21 | 123 / 578 | 47% | 3.04 | 544 / 1155 |
| kidney | 54% | 73.34 | 48 / 89 | 9% | 0.57 | 81 / 901 |
| adipose | 52% | 150.99 | 627 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 35% | 38.54 | 84 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 30% | 45.77 | 405 / 1335 | 0% | 0 | 0 / 0 |
| heart | 26% | 38.73 | 223 / 861 | 0% | 0 | 0 / 0 |
| thymus | 15% | 19.12 | 99 / 653 | 10% | 0.79 | 59 / 605 |
| eye | 0% | 0 | 0 / 0 | 21% | 0.68 | 17 / 80 |
| liver | 3% | 3.01 | 7 / 226 | 16% | 1.78 | 66 / 406 |
| adrenal gland | 0% | 1.66 | 1 / 258 | 13% | 0.74 | 29 / 230 |
| muscle | 0% | 0.33 | 3 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.12 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_0043204 | Cellular component | perikaryon |
| GO_0045121 | Cellular component | membrane raft |
| GO_0098552 | Cellular component | side of membrane |
| GO_0045202 | Cellular component | synapse |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030425 | Cellular component | dendrite |
| GO_0005515 | Molecular function | protein binding |
| GO_0030550 | Molecular function | acetylcholine receptor inhibitor activity |
| Gene name | LYPD6 |
| Protein name | Ly6/PLAUR domain-containing protein 6 LY6/PLAUR domain containing 6 |
| Synonyms | UNQ3023/PRO9821 |
| Description | FUNCTION: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain . Inhibits nicotine-induced Ca(2+) influx through nAChRs . In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner . Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). . |
| Accessions | C9IYE7 ENST00000392854.4 [Q86Y78-2] ENST00000418762.5 [Q86Y78-2] ENST00000651933.1 [Q86Y78-1] ENST00000409381.5 [Q86Y78-1] ENST00000414420.5 ENST00000334166.9 [Q86Y78-1] Q86Y78 |
