FZD9 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FZD9 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FZD9 at tissue level.

III. Associated gene sets

GO_0051480Biological processregulation of cytosolic calcium ion concentration
GO_0099173Biological processpostsynapse organization
GO_0099566Biological processregulation of postsynaptic cytosolic calcium ion concentration
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0007611Biological processlearning or memory
GO_1901029Biological processnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0060070Biological processcanonical Wnt signaling pathway
GO_1990523Biological processbone regeneration
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_2000179Biological processpositive regulation of neural precursor cell proliferation
GO_0060546Biological processnegative regulation of necroptotic process
GO_0051902Biological processnegative regulation of mitochondrial depolarization
GO_0001836Biological processrelease of cytochrome c from mitochondria
GO_1904393Biological processregulation of skeletal muscle acetylcholine-gated channel clustering
GO_1904394Biological processnegative regulation of skeletal muscle acetylcholine-gated channel clustering
GO_0001503Biological processossification
GO_0035567Biological processnon-canonical Wnt signaling pathway
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0051726Biological processregulation of cell cycle
GO_0043065Biological processpositive regulation of apoptotic process
GO_0030501Biological processpositive regulation of bone mineralization
GO_0007399Biological processnervous system development
GO_0030183Biological processB cell differentiation
GO_0007405Biological processneuroblast proliferation
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0098794Cellular componentpostsynapse
GO_0005794Cellular componentGolgi apparatus
GO_0031527Cellular componentfilopodium membrane
GO_0009986Cellular componentcell surface
GO_0005737Cellular componentcytoplasm
GO_0017147Molecular functionWnt-protein binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0042813Molecular functionWnt receptor activity
GO_0046982Molecular functionprotein heterodimerization activity

IV. Literature review

[source]
Gene nameFZD9
Protein nameFrizzled-9 (Fz-9) (hFz9) (FzE6) (CD antigen CD349)
Frizzled homolog 9 (Drosophila)
SynonymsFZD3
DescriptionFUNCTION: Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process . During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). .

AccessionsQ8TAN2
ENST00000344575.5
O00144