PPM1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0006470Biological processprotein dephosphorylation
GO_0006611Biological processprotein export from nucleus
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0035970Biological processpeptidyl-threonine dephosphorylation
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0016311Biological processdephosphorylation
GO_0006499Biological processN-terminal protein myristoylation
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0051726Biological processregulation of cell cycle
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0070412Molecular functionR-SMAD binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0030145Molecular functionmanganese ion binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0033192Molecular functioncalmodulin-dependent protein phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPM1A
Protein nameProtein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA)
Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha)
Alternative protein PPM1A
Protein phosphatase 1A (Protein phosphatase 2C isoform alpha)
Protein phosphatase, Mg2+/Mn2+ dependent 1A
SynonymsPPPM1A
DescriptionFUNCTION: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. .

AccessionsE9PJN3
E9PP44
B5BUD5
ENST00000325658.3 [P35813-2]
E9PKB5
E9PL75
ENST00000531937.1
ENST00000532036.2
ENST00000531143.6
E9PNE1
L8EAT3
ENST00000325642.7 [P35813-3]
ENST00000395076.9 [P35813-1]
ENST00000525399.2
ENST00000528241.2
P35813