I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 6 studies | 23% ± 5% | |
| fibroblast | 6 studies | 25% ± 10% | |
| smooth muscle cell | 5 studies | 20% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 6 studies | 23% ± 5% | |
| fibroblast | 6 studies | 25% ± 10% | |
| smooth muscle cell | 5 studies | 20% ± 5% |
Insufficient scRNA-seq data for expression of PLEKHA4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 96% | 1948.93 | 1740 / 1809 | 99% | 126.35 | 465 / 472 |
| ovary | 100% | 4795.22 | 180 / 180 | 94% | 39.67 | 405 / 430 |
| uterus | 100% | 4042.31 | 170 / 170 | 88% | 39.96 | 404 / 459 |
| kidney | 100% | 2336.49 | 89 / 89 | 88% | 38.62 | 793 / 901 |
| esophagus | 96% | 3081.70 | 1388 / 1445 | 91% | 28.47 | 167 / 183 |
| thymus | 100% | 3660.49 | 650 / 653 | 88% | 90.42 | 531 / 605 |
| prostate | 100% | 3128.81 | 244 / 245 | 86% | 19.81 | 432 / 502 |
| breast | 100% | 3831.60 | 457 / 459 | 81% | 30.25 | 901 / 1118 |
| lung | 99% | 2813.66 | 573 / 578 | 78% | 20.95 | 900 / 1155 |
| intestine | 90% | 3108.81 | 874 / 966 | 83% | 25.88 | 438 / 527 |
| bladder | 100% | 3724.10 | 21 / 21 | 68% | 19.04 | 345 / 504 |
| adrenal gland | 100% | 2405.47 | 258 / 258 | 66% | 18.62 | 152 / 230 |
| stomach | 79% | 1839.13 | 282 / 359 | 87% | 27.86 | 250 / 286 |
| liver | 94% | 1588.61 | 213 / 226 | 64% | 15.98 | 259 / 406 |
| pancreas | 48% | 480.79 | 159 / 328 | 94% | 40.23 | 167 / 178 |
| brain | 27% | 369.87 | 724 / 2642 | 79% | 46.74 | 558 / 705 |
| eye | 0% | 0 | 0 / 0 | 100% | 48.53 | 80 / 80 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.38 | 1 / 1 |
| adipose | 100% | 3644.99 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 4525.12 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 2548.78 | 836 / 861 | 0% | 0 | 0 / 0 |
| spleen | 97% | 1561.83 | 233 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 25.92 | 40 / 45 |
| muscle | 86% | 1263.33 | 689 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 31% | 4.16 | 9 / 29 |
| peripheral blood | 6% | 58.84 | 59 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_2000096 | Biological process | positive regulation of Wnt signaling pathway, planar cell polarity pathway |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031234 | Cellular component | extrinsic component of cytoplasmic side of plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0080025 | Molecular function | phosphatidylinositol-3,5-bisphosphate binding |
| GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0032266 | Molecular function | phosphatidylinositol-3-phosphate binding |
| GO_0043325 | Molecular function | phosphatidylinositol-3,4-bisphosphate binding |
| Gene name | PLEKHA4 |
| Protein name | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) Pleckstrin homology domain containing A4 |
| Synonyms | PEPP1 |
| Description | FUNCTION: Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. . |
| Accessions | ENST00000594100.2 ENST00000706738.1 Q9H4M7 M0QXJ3 M0R0J1 M0R2K5 ENST00000263265.11 [Q9H4M7-1] A0A9L9PXT3 ENST00000595867.1 ENST00000594195.2 ENST00000355496.9 [Q9H4M7-2] |
