Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| brain | 20 studies | 40% ± 20% | |
| lung | 19 studies | 28% ± 9% | |
| eye | 10 studies | 32% ± 13% | |
| peripheral blood | 9 studies | 25% ± 9% | |
| intestine | 8 studies | 24% ± 12% | |
| liver | 6 studies | 27% ± 10% | |
| kidney | 5 studies | 24% ± 5% | |
| heart | 5 studies | 26% ± 5% | |
| adipose | 5 studies | 30% ± 10% | |
| uterus | 4 studies | 28% ± 11% | |
| breast | 4 studies | 19% ± 3% | |
| ovary | 3 studies | 18% ± 1% | |
| pancreas | 3 studies | 34% ± 16% | |
| skin | 3 studies | 24% ± 5% | |
| lymph node | 3 studies | 22% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 7775.05 | 459 / 459 | 100% | 36.06 | 1118 / 1118 |
| esophagus | 100% | 5684.58 | 1445 / 1445 | 100% | 36.59 | 183 / 183 |
| lung | 100% | 8762.60 | 578 / 578 | 100% | 36.95 | 1155 / 1155 |
| ovary | 100% | 6709.73 | 180 / 180 | 100% | 27.08 | 430 / 430 |
| pancreas | 100% | 3370.67 | 328 / 328 | 100% | 30.81 | 178 / 178 |
| prostate | 100% | 6161.40 | 245 / 245 | 100% | 34.81 | 502 / 502 |
| brain | 100% | 4853.82 | 2640 / 2642 | 100% | 58.16 | 705 / 705 |
| thymus | 100% | 5675.36 | 652 / 653 | 100% | 32.45 | 605 / 605 |
| uterus | 100% | 9496.64 | 170 / 170 | 100% | 30.62 | 458 / 459 |
| kidney | 100% | 3361.57 | 89 / 89 | 100% | 31.12 | 897 / 901 |
| bladder | 100% | 7975.52 | 21 / 21 | 99% | 27.71 | 501 / 504 |
| stomach | 100% | 4725.08 | 359 / 359 | 99% | 30.08 | 284 / 286 |
| adrenal gland | 100% | 4065.94 | 258 / 258 | 99% | 22.40 | 227 / 230 |
| intestine | 100% | 7856.76 | 966 / 966 | 98% | 27.01 | 519 / 527 |
| skin | 100% | 7359.97 | 1809 / 1809 | 98% | 35.83 | 463 / 472 |
| liver | 96% | 1884.47 | 217 / 226 | 89% | 11.22 | 362 / 406 |
| adipose | 100% | 9976.49 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 6606.95 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 34.36 | 29 / 29 |
| spleen | 100% | 5690.52 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 32.58 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 18.40 | 1 / 1 |
| muscle | 100% | 3470.30 | 800 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 8266.85 | 919 / 929 | 0% | 0 | 0 / 0 |
| heart | 97% | 3203.51 | 836 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 20.76 | 76 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0050673 | Biological process | epithelial cell proliferation |
| GO_0030279 | Biological process | negative regulation of ossification |
| GO_0030216 | Biological process | keratinocyte differentiation |
| GO_0001525 | Biological process | angiogenesis |
| GO_0001837 | Biological process | epithelial to mesenchymal transition |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0003198 | Biological process | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0048820 | Biological process | hair follicle maturation |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_0007507 | Biological process | heart development |
| GO_0060045 | Biological process | positive regulation of cardiac muscle cell proliferation |
| GO_0060844 | Biological process | arterial endothelial cell fate commitment |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0048505 | Biological process | regulation of timing of cell differentiation |
| GO_0072089 | Biological process | stem cell proliferation |
| GO_0003214 | Biological process | cardiac left ventricle morphogenesis |
| GO_0009957 | Biological process | epidermal cell fate specification |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_1901186 | Biological process | positive regulation of ERBB signaling pathway |
| GO_0002437 | Biological process | inflammatory response to antigenic stimulus |
| GO_2000241 | Biological process | regulation of reproductive process |
| GO_0061344 | Biological process | regulation of cell adhesion involved in heart morphogenesis |
| GO_0006959 | Biological process | humoral immune response |
| GO_0120163 | Biological process | negative regulation of cold-induced thermogenesis |
| GO_2000647 | Biological process | negative regulation of stem cell proliferation |
| GO_0007221 | Biological process | positive regulation of transcription of Notch receptor target |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0060486 | Biological process | club cell differentiation |
| GO_0043467 | Biological process | regulation of generation of precursor metabolites and energy |
| GO_0035912 | Biological process | dorsal aorta morphogenesis |
| GO_2000138 | Biological process | positive regulation of cell proliferation involved in heart morphogenesis |
| GO_0060716 | Biological process | labyrinthine layer blood vessel development |
| GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
| GO_0060379 | Biological process | cardiac muscle cell myoblast differentiation |
| GO_0001756 | Biological process | somitogenesis |
| GO_0043011 | Biological process | myeloid dendritic cell differentiation |
| GO_0060412 | Biological process | ventricular septum morphogenesis |
| GO_0003160 | Biological process | endocardium morphogenesis |
| GO_0003176 | Biological process | aortic valve development |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_0009912 | Biological process | auditory receptor cell fate commitment |
| GO_0045596 | Biological process | negative regulation of cell differentiation |
| GO_0036302 | Biological process | atrioventricular canal development |
| GO_0003177 | Biological process | pulmonary valve development |
| GO_0021983 | Biological process | pituitary gland development |
| GO_0097101 | Biological process | blood vessel endothelial cell fate specification |
| GO_0048733 | Biological process | sebaceous gland development |
| GO_0003139 | Biological process | secondary heart field specification |
| GO_0003222 | Biological process | ventricular trabecula myocardium morphogenesis |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_1901189 | Biological process | positive regulation of ephrin receptor signaling pathway |
| GO_0030183 | Biological process | B cell differentiation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0072554 | Biological process | blood vessel lumenization |
| GO_0035019 | Biological process | somatic stem cell population maintenance |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0017053 | Cellular component | transcription repressor complex |
| GO_0002193 | Cellular component | MAML1-RBP-Jkappa- ICN1 complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RBPJ |
| Protein name | Recombination signal binding protein for immunoglobulin kappa J region Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) Alternative protein RBPJ Recombining-binding protein suppressor of hairless |
| Synonyms | RBPJK IGKJRB IGKJRB1 RBPSUH |
| Description | FUNCTION: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA . Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) . Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). . |
| Accessions | ENST00000348160.9 [Q06330-6] A0A7P0T9Y9 D6RA45 A0A7P0TA33 D6R927 D6R946 ENST00000504423 ENST00000511546.5 ENST00000510778.7 Q06330 D6R9X3 ENST00000512351.5 ENST00000514730.5 ENST00000681799.1 ENST00000681506.1 D6RE93 ENST00000681484.1 [Q06330-5] ENST00000505958.6 [Q06330-6] A0A7P0T947 D6RAT2 D6REC2 ENST00000681093.1 [Q06330-6] A0A7P0T848 D6RIZ8 ENST00000679469.1 ENST00000681679.1 ENST00000680204.1 ENST00000515573.5 A0A7P0T821 ENST00000507574.5 D6RB37 D6REP3 A0A7P0T7Z3 D6RIV8 ENST00000514807.5 ENST00000512671 ENST00000680210.1 ENST00000680511.1 ENST00000681260.1 ENST00000504423.2 [Q06330-5] ENST00000345843.8 [Q06330-5] ENST00000342295.6 [Q06330-1] ENST00000509158.6 D6RBQ8 ENST00000355476.8 [Q06330-7] L8E7S3 ENST00000504907.5 ENST00000681856.1 ENST00000507561.5 [Q06330-5] ENST00000680928.1 [Q06330-6] ENST00000505958 ENST00000514675.5 A0A7P0T806 ENST00000513182.5 ENST00000504938.1 A0A7P0TBJ4 ENST00000506956.5 ENST00000342320.8 [Q06330-6] A0A7P0T9W9 D6RCM1 A0A7P0Z4N7 ENST00000681025.1 ENST00000361572.10 [Q06330-1] D6RF98 ENST00000679698.1 D6R9K5 ENST00000512671.6 [Q06330-1] ENST00000680140.1 A0A7P0T964 ENST00000681264.1 [Q06330-5] H0Y8R3 |
