CTDNEP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007498Biological processmesoderm development
GO_0007276Biological processgamete generation
GO_0006470Biological processprotein dephosphorylation
GO_0007077Biological processmitotic nuclear membrane disassembly
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0006998Biological processnuclear envelope organization
GO_0034504Biological processprotein localization to nucleus
GO_0010867Biological processpositive regulation of triglyceride biosynthetic process
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0005737Cellular componentcytoplasm
GO_0071595Cellular componentNem1-Spo7 phosphatase complex
GO_0031965Cellular componentnuclear membrane
GO_0005811Cellular componentlipid droplet
GO_0005635Cellular componentnuclear envelope
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0017018Molecular functionmyosin phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity

IV. Literature review

[source]
Gene nameCTDNEP1
Protein nameCTD nuclear envelope phosphatase 1 (EC 3.1.3.16) (Serine/threonine-protein phosphatase dullard)
protein-serine/threonine phosphatase (EC 3.1.3.16)
CTD nuclear envelope phosphatase 1
SynonymsDULLARD
DescriptionFUNCTION: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. .

AccessionsI3L2R5
ENST00000574322.6
ENST00000574205.5
ENST00000573600.5
O95476
ENST00000572043.5
ENST00000570828.5
ENST00000318988.10
I3L1D9
I3L4B2
ENST00000570380.5
ENST00000575783.5
I3L0X6
ENST00000571409.1
ENST00000576613.5
I3L3K5
I3L4W0