WNT3A | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WNT3A at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	544.52	574 / 578	44%	3.53	505 / 1155
prostate	87%	202.90	214 / 245	54%	1.61	272 / 502
ureter	0%	0	0 / 0	100%	3.07	1 / 1
tonsil	0%	0	0 / 0	91%	6.89	41 / 45
esophagus	38%	50.22	551 / 1445	46%	4.77	84 / 183
skin	72%	168.25	1298 / 1809	2%	0.04	8 / 472
uterus	6%	7.67	11 / 170	45%	2.91	208 / 459
kidney	29%	12.06	26 / 89	2%	0.04	22 / 901
ovary	1%	0.36	1 / 180	18%	0.66	78 / 430
bladder	5%	1.62	1 / 21	12%	0.76	62 / 504
breast	5%	2.00	24 / 459	6%	0.29	72 / 1118
liver	0%	0	0 / 226	9%	1.82	35 / 406
thymus	1%	0.18	4 / 653	3%	0.18	18 / 605
pancreas	0%	0	0 / 328	3%	0.12	5 / 178
peripheral blood	3%	2.77	26 / 929	0%	0	0 / 0
intestine	1%	0.22	5 / 966	2%	0.13	11 / 527
stomach	0%	0.08	1 / 359	1%	0.06	4 / 286
adrenal gland	0%	0	0 / 258	1%	0.10	3 / 230
brain	0%	0.15	12 / 2642	1%	0.03	4 / 705
muscle	1%	0.23	6 / 803	0%	0	0 / 0
adipose	0%	0.23	4 / 1204	0%	0	0 / 0
blood vessel	0%	0.23	4 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

III. Associated gene sets

GO_0036465	Biological process	synaptic vesicle recycling
GO_0006366	Biological process	transcription by RNA polymerase II
GO_0008283	Biological process	cell population proliferation
GO_0048103	Biological process	somatic stem cell division
GO_0048343	Biological process	paraxial mesodermal cell fate commitment
GO_0070527	Biological process	platelet aggregation
GO_0001947	Biological process	heart looping
GO_0060923	Biological process	cardiac muscle cell fate commitment
GO_2000179	Biological process	positive regulation of neural precursor cell proliferation
GO_0036342	Biological process	post-anal tail morphogenesis
GO_0099054	Biological process	presynapse assembly
GO_1905539	Biological process	regulation of postsynapse to nucleus signaling pathway
GO_0071300	Biological process	cellular response to retinoic acid
GO_0030879	Biological process	mammary gland development
GO_0090676	Biological process	calcium ion transmembrane transport via low voltage-gated calcium channel
GO_0090245	Biological process	axis elongation involved in somitogenesis
GO_0021846	Biological process	cell proliferation in forebrain
GO_0001701	Biological process	in utero embryonic development
GO_0001649	Biological process	osteoblast differentiation
GO_0010628	Biological process	positive regulation of gene expression
GO_0045599	Biological process	negative regulation of fat cell differentiation
GO_0050807	Biological process	regulation of synapse organization
GO_0030182	Biological process	neuron differentiation
GO_0045165	Biological process	cell fate commitment
GO_0042472	Biological process	inner ear morphogenesis
GO_0070507	Biological process	regulation of microtubule cytoskeleton organization
GO_0035567	Biological process	non-canonical Wnt signaling pathway
GO_0001819	Biological process	positive regulation of cytokine production
GO_0048843	Biological process	negative regulation of axon extension involved in axon guidance
GO_2000347	Biological process	positive regulation of hepatocyte proliferation
GO_0021766	Biological process	hippocampus development
GO_0021527	Biological process	spinal cord association neuron differentiation
GO_0030097	Biological process	hemopoiesis
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0010387	Biological process	COP9 signalosome assembly
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0061184	Biological process	positive regulation of dermatome development
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0048643	Biological process	positive regulation of skeletal muscle tissue development
GO_1904339	Biological process	negative regulation of dopaminergic neuron differentiation
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0033278	Biological process	cell proliferation in midbrain
GO_0030890	Biological process	positive regulation of B cell proliferation
GO_0045445	Biological process	myoblast differentiation
GO_2000049	Biological process	positive regulation of cell-cell adhesion mediated by cadherin
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0042100	Biological process	B cell proliferation
GO_0035914	Biological process	skeletal muscle cell differentiation
GO_0021874	Biological process	Wnt signaling pathway involved in forebrain neuroblast division
GO_0045444	Biological process	fat cell differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0048697	Biological process	positive regulation of collateral sprouting in absence of injury
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_1905606	Biological process	regulation of presynapse assembly
GO_1904948	Biological process	midbrain dopaminergic neuron differentiation
GO_0007507	Biological process	heart development
GO_0048337	Biological process	positive regulation of mesodermal cell fate specification
GO_2000727	Biological process	positive regulation of cardiac muscle cell differentiation
GO_0030198	Biological process	extracellular matrix organization
GO_0062009	Biological process	secondary palate development
GO_0021904	Biological process	dorsal/ventral neural tube patterning
GO_0002092	Biological process	positive regulation of receptor internalization
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0008104	Biological process	protein localization
GO_0050768	Biological process	negative regulation of neurogenesis
GO_0007411	Biological process	axon guidance
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0009986	Cellular component	cell surface
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005576	Cellular component	extracellular region
GO_0031901	Cellular component	early endosome membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005615	Cellular component	extracellular space
GO_1990851	Cellular component	Wnt-Frizzled-LRP5/6 complex
GO_0005886	Cellular component	plasma membrane
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0005796	Cellular component	Golgi lumen
GO_0048018	Molecular function	receptor ligand activity
GO_0042802	Molecular function	identical protein binding
GO_0005102	Molecular function	signaling receptor binding
GO_0005125	Molecular function	cytokine activity
GO_0039706	Molecular function	co-receptor binding
GO_0019904	Molecular function	protein domain specific binding
GO_0005515	Molecular function	protein binding
GO_0005109	Molecular function	frizzled binding
GO_0003713	Molecular function	transcription coactivator activity

Gene name	WNT3A
Protein name	Protein Wnt-3a
Synonyms
Description	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family . Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) . .
Accessions	P56704 ENST00000284523.2 [P56704-1]

WNT3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review