NRARP | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of NRARP at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	97%	825.84	238 / 245	95%	21.89	477 / 502
stomach	92%	405.39	332 / 359	99%	88.14	283 / 286
breast	97%	597.22	446 / 459	89%	20.77	999 / 1118
esophagus	87%	748.21	1257 / 1445	99%	122.14	182 / 183
pancreas	95%	375.73	312 / 328	90%	20.92	161 / 178
brain	91%	392.07	2397 / 2642	94%	33.41	666 / 705
intestine	86%	1166.49	827 / 966	99%	89.94	520 / 527
uterus	91%	370.84	155 / 170	86%	41.41	397 / 459
lung	97%	601.21	562 / 578	74%	34.77	854 / 1155
bladder	86%	486.95	18 / 21	77%	42.70	388 / 504
thymus	96%	444.08	624 / 653	52%	8.96	315 / 605
kidney	88%	267.82	78 / 89	56%	17.10	506 / 901
ovary	49%	134.72	88 / 180	93%	29.47	400 / 430
tonsil	0%	0	0 / 0	100%	38.10	45 / 45
ureter	0%	0	0 / 0	100%	12.47	1 / 1
heart	98%	522.79	840 / 861	0%	0	0 / 0
adipose	97%	629.80	1170 / 1204	0%	0	0 / 0
skin	72%	1132.20	1302 / 1809	17%	2.88	82 / 472
spleen	88%	326.65	213 / 241	0%	0	0 / 0
adrenal gland	40%	91.70	102 / 258	45%	8.87	104 / 230
liver	32%	76.65	72 / 226	27%	6.67	108 / 406
blood vessel	55%	168.65	734 / 1335	0%	0	0 / 0
muscle	40%	84.12	320 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	18%	1.78	14 / 80
peripheral blood	12%	28.38	111 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0002043	Biological process	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0030217	Biological process	T cell differentiation
GO_0001569	Biological process	branching involved in blood vessel morphogenesis
GO_0101023	Biological process	vascular endothelial cell proliferation
GO_1905564	Biological process	positive regulation of vascular endothelial cell proliferation
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_0045746	Biological process	negative regulation of Notch signaling pathway
GO_0007219	Biological process	Notch signaling pathway
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0045581	Biological process	negative regulation of T cell differentiation
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0032525	Biological process	somite rostral/caudal axis specification
GO_0005515	Molecular function	protein binding

Gene name	NRARP
Protein name	Notch-regulated ankyrin repeat-containing protein
Synonyms
Description	FUNCTION: Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal . Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis . During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity). .
Accessions	Q7Z6K4 ENST00000356628.4

NRARP report