CSNK1D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905515Biological processnon-motile cilium assembly
GO_0061512Biological processprotein localization to cilium
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0006897Biological processendocytosis
GO_1904948Biological processmidbrain dopaminergic neuron differentiation
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0007165Biological processsignal transduction
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0071539Biological processprotein localization to centrosome
GO_0007020Biological processmicrotubule nucleation
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0032922Biological processcircadian regulation of gene expression
GO_0042752Biological processregulation of circadian rhythm
GO_0034067Biological processprotein localization to Golgi apparatus
GO_0007030Biological processGolgi organization
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0051225Biological processspindle assembly
GO_0016055Biological processWnt signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_2000052Biological processpositive regulation of non-canonical Wnt signaling pathway
GO_0048208Biological processCOPII vesicle coating
GO_0005876Cellular componentspindle microtubule
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0036064Cellular componentciliary basal body
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0045296Molecular functioncadherin binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0050321Molecular functiontau-protein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCSNK1D
Protein nameCasein kinase 1 delta
Casein kinase I isoform delta (EC 2.7.11.26) (Tau-protein kinase CSNK1D)
Casein kinase I isoform delta (EC 2.7.11.1) (EC 2.7.11.26) (Tau-protein kinase CSNK1D)
Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
SynonymsHCKID
DescriptionFUNCTION: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. .

AccessionsB4DLF1
J3QQI9
ENST00000584672.1
ENST00000580446.1
ENST00000269361.11
J3KRM8
ENST00000392334.7 [P48730-2]
ENST00000314028.11 [P48730-1]
H7BYT1
ENST00000580784.5
ENST00000398519.9
J3QQU8
P48730
ENST00000403276.7
ENST00000585026.1
J3KRS6
ENST00000581660.5
J3QS70
H0Y2N6