TNKS2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	19 studies	27% ± 13%	Explore
ciliated cell	11 studies	24% ± 10%	Explore
astrocyte	11 studies	31% ± 14%	Explore
macrophage	10 studies	28% ± 10%	Explore
glutamatergic neuron	9 studies	41% ± 25%	Explore
microglial cell	9 studies	29% ± 10%	Explore
oligodendrocyte precursor cell	9 studies	27% ± 13%	Explore
GABAergic neuron	8 studies	39% ± 22%	Explore
fibroblast	8 studies	22% ± 10%	Explore
oligodendrocyte	8 studies	27% ± 9%	Explore
T cell	7 studies	21% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	18% ± 2%	Explore
dendritic cell	7 studies	26% ± 11%	Explore
plasmacytoid dendritic cell	7 studies	24% ± 7%	Explore
natural killer cell	6 studies	19% ± 2%	Explore
classical monocyte	6 studies	21% ± 6%	Explore
interneuron	6 studies	40% ± 24%	Explore
epithelial cell	6 studies	42% ± 21%	Explore
basal cell	6 studies	30% ± 20%	Explore
club cell	6 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	6 studies	16% ± 1%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 3%	Explore
CD4-positive, alpha-beta T cell	5 studies	16% ± 1%	Explore
neuron	5 studies	28% ± 12%	Explore
naive B cell	5 studies	17% ± 2%	Explore
myeloid cell	5 studies	23% ± 4%	Explore
endothelial cell of lymphatic vessel	5 studies	23% ± 6%	Explore
type II pneumocyte	5 studies	20% ± 6%	Explore
monocyte	5 studies	22% ± 5%	Explore
type I pneumocyte	5 studies	21% ± 7%	Explore
smooth muscle cell	5 studies	18% ± 2%	Explore
B cell	4 studies	18% ± 3%	Explore
secretory cell	4 studies	18% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	19% ± 1%	Explore
non-classical monocyte	4 studies	22% ± 8%	Explore
granule cell	4 studies	22% ± 4%	Explore
retinal cone cell	4 studies	22% ± 7%	Explore
adipocyte	4 studies	19% ± 4%	Explore
lymphocyte	4 studies	27% ± 10%	Explore
pericyte	4 studies	22% ± 8%	Explore
mucosal invariant T cell	4 studies	18% ± 1%	Explore
regulatory T cell	4 studies	18% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	17% ± 1%	Explore
hematopoietic precursor cell	3 studies	19% ± 1%	Explore
plasmablast	3 studies	21% ± 4%	Explore
GABAergic interneuron	3 studies	23% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	18% ± 2%	Explore
squamous epithelial cell	3 studies	35% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 0%	Explore
retinal rod cell	3 studies	22% ± 4%	Explore
hepatocyte	3 studies	34% ± 26%	Explore
alveolar macrophage	3 studies	28% ± 8%	Explore
gamma-delta T cell	3 studies	23% ± 5%	Explore
memory B cell	3 studies	16% ± 0%	Explore
muscle cell	3 studies	31% ± 18%	Explore
goblet cell	3 studies	41% ± 30%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	35% ± 19%	Explore
peripheral blood	5 studies	19% ± 2%	Explore
lung	5 studies	23% ± 5%	Explore
eye	3 studies	33% ± 15%	Explore
liver	3 studies	25% ± 12%	Explore
adipose	3 studies	19% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4847.91	1445 / 1445	100%	50.21	183 / 183
lung	100%	4806.47	578 / 578	100%	41.01	1155 / 1155
brain	100%	3536.75	2631 / 2642	100%	46.82	705 / 705
ovary	100%	5940.85	180 / 180	100%	29.87	428 / 430
thymus	100%	5922.00	653 / 653	100%	51.50	602 / 605
pancreas	100%	2902.43	328 / 328	99%	35.54	177 / 178
bladder	100%	4319.38	21 / 21	99%	35.35	501 / 504
breast	100%	5078.89	459 / 459	99%	49.59	1108 / 1118
intestine	100%	4065.21	966 / 966	99%	30.30	522 / 527
prostate	100%	4040.15	245 / 245	99%	40.03	497 / 502
stomach	100%	3476.74	359 / 359	99%	32.90	282 / 286
uterus	100%	5071.95	170 / 170	98%	36.44	451 / 459
adrenal gland	100%	4099.36	258 / 258	97%	28.87	224 / 230
kidney	100%	2698.02	89 / 89	97%	31.72	872 / 901
skin	100%	6105.39	1809 / 1809	94%	32.14	444 / 472
liver	100%	2185.01	226 / 226	85%	15.85	344 / 406
adipose	100%	4777.75	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5270.85	1335 / 1335	0%	0	0 / 0
muscle	100%	5876.53	803 / 803	0%	0	0 / 0
spleen	100%	5271.59	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	14.26	1 / 1
tonsil	0%	0	0 / 0	98%	37.27	44 / 45
heart	96%	1950.04	823 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	30.98	27 / 29
peripheral blood	89%	2405.97	823 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	74%	14.56	59 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1904355	Biological process	positive regulation of telomere capping
GO_0000209	Biological process	protein polyubiquitination
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_1904357	Biological process	negative regulation of telomere maintenance via telomere lengthening
GO_0070198	Biological process	protein localization to chromosome, telomeric region
GO_0070212	Biological process	protein poly-ADP-ribosylation
GO_0016055	Biological process	Wnt signaling pathway
GO_0070213	Biological process	protein auto-ADP-ribosylation
GO_0032212	Biological process	positive regulation of telomere maintenance via telomerase
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005635	Cellular component	nuclear envelope
GO_0000139	Cellular component	Golgi membrane
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0000242	Cellular component	pericentriolar material
GO_0000781	Cellular component	chromosome, telomeric region
GO_0005634	Cellular component	nucleus
GO_0016779	Molecular function	nucleotidyltransferase activity
GO_0019899	Molecular function	enzyme binding
GO_0003950	Molecular function	NAD+ ADP-ribosyltransferase activity
GO_0046872	Molecular function	metal ion binding
GO_1990404	Molecular function	NAD+-protein ADP-ribosyltransferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TNKS2
Protein name	Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein) Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-)
Synonyms	TANK2 TNKL PARP5B
Description	FUNCTION: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking . Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation . Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination . Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length . Stimulates 26S proteasome activity . .
Accessions	A0AA34QVI1 Q9H2K2 ENST00000371627.5 ENST00000710380.1

TNKS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review