RNF220 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051865Biological processprotein autoubiquitination
GO_0016567Biological processprotein ubiquitination
GO_2000677Biological processregulation of transcription regulatory region DNA binding
GO_0003358Biological processnoradrenergic neuron development
GO_0006513Biological processprotein monoubiquitination
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0021904Biological processdorsal/ventral neural tube patterning
GO_0005652Cellular componentnuclear lamina
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0008013Molecular functionbeta-catenin binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF220
Protein nameRNF220 protein
E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220)
Ring finger protein 220
SynonymsC1orf164
DescriptionFUNCTION: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling . Plays a critical role in the regulation of nuclear lamina . .

AccessionsQ5TDE8
Q5TDE7
U3KPZ6
ENST00000335497.11
ENST00000355387.6 [Q5VTB9-1]
ENST00000453863.5
ENST00000440132.2
H0Y7B1
Q5VTB9
Q9BWG1
ENST00000361799.7 [Q5VTB9-1]
ENST00000488865.2