TBL1XR1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	31 studies	36% ± 16%	Explore
fibroblast	27 studies	31% ± 14%	Explore
astrocyte	19 studies	42% ± 17%	Explore
macrophage	18 studies	35% ± 18%	Explore
pericyte	16 studies	31% ± 13%	Explore
smooth muscle cell	15 studies	30% ± 14%	Explore
oligodendrocyte	15 studies	47% ± 15%	Explore
oligodendrocyte precursor cell	15 studies	49% ± 17%	Explore
microglial cell	15 studies	53% ± 17%	Explore
basal cell	13 studies	40% ± 22%	Explore
ciliated cell	13 studies	40% ± 16%	Explore
glutamatergic neuron	13 studies	56% ± 23%	Explore
T cell	12 studies	26% ± 11%	Explore
endothelial cell of lymphatic vessel	12 studies	33% ± 14%	Explore
B cell	11 studies	29% ± 10%	Explore
GABAergic neuron	11 studies	53% ± 21%	Explore
epithelial cell	11 studies	46% ± 21%	Explore
type I pneumocyte	9 studies	37% ± 17%	Explore
myeloid cell	9 studies	34% ± 12%	Explore
adipocyte	9 studies	49% ± 13%	Explore
plasmacytoid dendritic cell	9 studies	25% ± 9%	Explore
natural killer cell	8 studies	24% ± 8%	Explore
CD8-positive, alpha-beta T cell	8 studies	24% ± 7%	Explore
neuron	8 studies	49% ± 20%	Explore
amacrine cell	8 studies	42% ± 16%	Explore
dendritic cell	8 studies	47% ± 17%	Explore
monocyte	8 studies	33% ± 11%	Explore
regulatory T cell	8 studies	25% ± 9%	Explore
CD4-positive, alpha-beta T cell	7 studies	28% ± 6%	Explore
club cell	7 studies	43% ± 14%	Explore
retinal cone cell	7 studies	43% ± 19%	Explore
retinal rod cell	7 studies	40% ± 23%	Explore
leukocyte	6 studies	41% ± 21%	Explore
myofibroblast cell	6 studies	28% ± 15%	Explore
connective tissue cell	6 studies	33% ± 10%	Explore
interneuron	6 studies	63% ± 17%	Explore
retina horizontal cell	6 studies	49% ± 19%	Explore
mast cell	6 studies	30% ± 15%	Explore
mesothelial cell	6 studies	36% ± 12%	Explore
Mueller cell	6 studies	32% ± 18%	Explore
endothelial cell of vascular tree	6 studies	26% ± 14%	Explore
type II pneumocyte	6 studies	37% ± 12%	Explore
goblet cell	6 studies	34% ± 23%	Explore
secretory cell	5 studies	28% ± 15%	Explore
retinal bipolar neuron	5 studies	39% ± 13%	Explore
progenitor cell	5 studies	33% ± 14%	Explore
retinal ganglion cell	5 studies	36% ± 22%	Explore
cardiac muscle cell	5 studies	44% ± 11%	Explore
vein endothelial cell	5 studies	30% ± 16%	Explore
lymphocyte	5 studies	36% ± 16%	Explore
respiratory goblet cell	5 studies	41% ± 16%	Explore
capillary endothelial cell	5 studies	28% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	25% ± 6%	Explore
classical monocyte	4 studies	23% ± 6%	Explore
conventional dendritic cell	4 studies	24% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	29% ± 5%	Explore
epithelial cell of proximal tubule	4 studies	20% ± 6%	Explore
abnormal cell	4 studies	40% ± 18%	Explore
gamma-delta T cell	4 studies	26% ± 12%	Explore
granule cell	4 studies	48% ± 6%	Explore
plasma cell	4 studies	47% ± 10%	Explore
retinal pigment epithelial cell	4 studies	41% ± 23%	Explore
endothelial cell of artery	4 studies	22% ± 4%	Explore
hepatocyte	4 studies	52% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	27% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	19% ± 5%	Explore
hematopoietic precursor cell	3 studies	46% ± 18%	Explore
non-classical monocyte	3 studies	28% ± 8%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	50% ± 10%	Explore
neural crest cell	3 studies	17% ± 2%	Explore
GABAergic interneuron	3 studies	48% ± 3%	Explore
glial cell	3 studies	37% ± 11%	Explore
squamous epithelial cell	3 studies	45% ± 22%	Explore
brush cell	3 studies	29% ± 10%	Explore
mononuclear phagocyte	3 studies	35% ± 5%	Explore
mucosal invariant T cell	3 studies	23% ± 5%	Explore
GABAergic amacrine cell	3 studies	56% ± 18%	Explore
OFF-bipolar cell	3 studies	47% ± 14%	Explore
ON-bipolar cell	3 studies	55% ± 15%	Explore
glycinergic amacrine cell	3 studies	42% ± 12%	Explore
rod bipolar cell	3 studies	54% ± 18%	Explore
innate lymphoid cell	3 studies	19% ± 2%	Explore
mature NK T cell	3 studies	29% ± 18%	Explore
muscle cell	3 studies	33% ± 20%	Explore
ependymal cell	3 studies	62% ± 9%	Explore
intestinal crypt stem cell	3 studies	22% ± 3%	Explore
adventitial cell	3 studies	29% ± 10%	Explore
alveolar macrophage	3 studies	41% ± 12%	Explore
chondrocyte	3 studies	38% ± 14%	Explore
transit amplifying cell	3 studies	44% ± 36%	Explore
renal alpha-intercalated cell	3 studies	25% ± 8%	Explore
renal principal cell	3 studies	28% ± 6%	Explore
mural cell	3 studies	48% ± 5%	Explore
mucus secreting cell	3 studies	40% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	50% ± 19%	Explore
lung	10 studies	36% ± 14%	Explore
eye	8 studies	44% ± 22%	Explore
kidney	5 studies	25% ± 9%	Explore
heart	5 studies	34% ± 10%	Explore
intestine	5 studies	22% ± 8%	Explore
liver	4 studies	39% ± 19%	Explore
peripheral blood	3 studies	33% ± 7%	Explore
adipose	3 studies	43% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5724.76	1445 / 1445	100%	79.49	183 / 183
lung	100%	6862.08	578 / 578	100%	65.84	1155 / 1155
ovary	100%	6327.65	180 / 180	100%	61.94	430 / 430
uterus	100%	6121.31	170 / 170	100%	57.82	459 / 459
brain	100%	5576.43	2640 / 2642	100%	35.30	705 / 705
breast	100%	6676.70	459 / 459	100%	65.20	1117 / 1118
prostate	100%	8546.58	245 / 245	100%	63.96	501 / 502
thymus	100%	10770.16	653 / 653	100%	55.76	603 / 605
bladder	100%	5911.33	21 / 21	99%	49.74	501 / 504
intestine	100%	7023.31	966 / 966	98%	41.49	518 / 527
pancreas	99%	3172.13	326 / 328	99%	39.32	176 / 178
stomach	100%	4256.75	359 / 359	98%	41.87	281 / 286
kidney	100%	4762.91	89 / 89	98%	43.87	882 / 901
adrenal gland	100%	6712.12	258 / 258	94%	23.09	216 / 230
skin	100%	6985.98	1809 / 1809	90%	28.70	426 / 472
liver	100%	3415.36	226 / 226	85%	18.82	347 / 406
lymph node	0%	0	0 / 0	100%	49.10	29 / 29
spleen	100%	6948.27	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	62.60	45 / 45
ureter	0%	0	0 / 0	100%	19.17	1 / 1
adipose	100%	6442.23	1203 / 1204	0%	0	0 / 0
blood vessel	100%	6724.87	1333 / 1335	0%	0	0 / 0
muscle	100%	3426.05	801 / 803	0%	0	0 / 0
heart	99%	4606.83	851 / 861	0%	0	0 / 0
peripheral blood	88%	3527.47	822 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	61%	10.90	49 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0001835	Biological process	blastocyst hatching
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0035264	Biological process	multicellular organism growth
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0002021	Biological process	response to dietary excess
GO_0016042	Biological process	lipid catabolic process
GO_0060613	Biological process	fat pad development
GO_0090207	Biological process	regulation of triglyceride metabolic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0050872	Biological process	white fat cell differentiation
GO_0072686	Cellular component	mitotic spindle
GO_0005654	Cellular component	nucleoplasm
GO_0017053	Cellular component	transcription repressor complex
GO_0000118	Cellular component	histone deacetylase complex
GO_0005634	Cellular component	nucleus
GO_0042393	Molecular function	histone binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0008013	Molecular function	beta-catenin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TBL1XR1
Protein name	TBL1X/Y related 1 DC42 (HCG2039387) (TBL1XR1 protein) F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)
Synonyms	IRA1 hCG_2039387 TBLR1
Description	FUNCTION: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. .
Accessions	A0A0D9SEW5 ENST00000428970.5 C9JCK0 ENST00000630796.2 A0A1B0GUU2 C9JBN1 ENST00000635794.1 ENST00000424913.5 ENST00000430069.5 A0A1B0GVH3 Q9BZK7 ENST00000427349.5 ENST00000704384.1 ENST00000626758.1 ENST00000437738.5 C9JCW4 C9J903 Q9H2I4 C9JLJ1 A0A0D9SF63 ENST00000431421.6 ENST00000631253.2 ENST00000450267.5 ENST00000637659.1 ENST00000457928.7 A0A0D9SFI2 C9IYU9 C9J3H2 ENST00000704385.1 C9J7E1 ENST00000352800.10 ENST00000704383.1 ENST00000630833.2 ENST00000413084.5 C9JEC9 A0A0D9SF25 ENST00000673974.1 ENST00000422442.6 ENST00000443315.5 ENST00000422066.6 ENST00000431674.5 C9JTW8

TBL1XR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review