RSPO3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of RSPO3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	98%	1618.71	452 / 459	65%	2.23	730 / 1118
prostate	74%	796.41	181 / 245	77%	3.03	387 / 502
uterus	98%	4758.82	167 / 170	49%	8.27	223 / 459
esophagus	88%	3378.90	1265 / 1445	55%	3.36	101 / 183
stomach	79%	1397.70	283 / 359	63%	3.70	181 / 286
intestine	84%	981.36	814 / 966	51%	2.72	270 / 527
lung	76%	595.34	441 / 578	56%	4.19	652 / 1155
bladder	81%	880.95	17 / 21	40%	1.45	201 / 504
adrenal gland	95%	1652.54	246 / 258	25%	1.28	58 / 230
lymph node	0%	0	0 / 0	93%	2.46	27 / 29
muscle	92%	1166.89	740 / 803	0%	0	0 / 0
thymus	72%	445.99	468 / 653	19%	0.44	116 / 605
adipose	85%	1935.53	1022 / 1204	0%	0	0 / 0
ovary	14%	406.72	26 / 180	68%	7.68	294 / 430
kidney	48%	436.57	43 / 89	34%	1.36	304 / 901
pancreas	8%	29.10	25 / 328	65%	3.42	116 / 178
liver	47%	206.02	107 / 226	10%	0.92	42 / 406
brain	24%	118.16	645 / 2642	30%	0.89	210 / 705
blood vessel	54%	416.59	720 / 1335	0%	0	0 / 0
skin	27%	137.08	489 / 1809	22%	0.54	102 / 472
tonsil	0%	0	0 / 0	31%	0.71	14 / 45
spleen	15%	105.11	37 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.09	3 / 80
heart	2%	5.84	13 / 861	0%	0	0 / 0
peripheral blood	0%	0.70	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0001974	Biological process	blood vessel remodeling
GO_2000052	Biological process	positive regulation of non-canonical Wnt signaling pathway
GO_2000096	Biological process	positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0060670	Biological process	branching involved in labyrinthine layer morphogenesis
GO_0002040	Biological process	sprouting angiogenesis
GO_0005576	Cellular component	extracellular region
GO_0008201	Molecular function	heparin binding
GO_0005109	Molecular function	frizzled binding
GO_0005102	Molecular function	signaling receptor binding

Gene name	RSPO3
Protein name	R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2)
Synonyms	PWTSR THSD2
Description	FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway . Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) . Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 . .
Accessions	Q9BXY4 ENST00000368317.3 [Q9BXY4-2] ENST00000356698.9 [Q9BXY4-1]

RSPO3 report