USP8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_0007265Biological processRas protein signal transduction
GO_1905908Biological processpositive regulation of amyloid fibril formation
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_1905166Biological processnegative regulation of lysosomal protein catabolic process
GO_0032880Biological processregulation of protein localization
GO_0000281Biological processmitotic cytokinesis
GO_0099576Biological processregulation of protein catabolic process at postsynapse, modulating synaptic transmission
GO_0070536Biological processprotein K63-linked deubiquitination
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0006508Biological processproteolysis
GO_0007032Biological processendosome organization
GO_0016579Biological processprotein deubiquitination
GO_0031647Biological processregulation of protein stability
GO_0098978Cellular componentglutamatergic synapse
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0005769Cellular componentearly endosome
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005634Cellular componentnucleus
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0045296Molecular functioncadherin binding
GO_1990380Molecular functionK48-linked deubiquitinase activity
GO_0061578Molecular functionK63-linked deubiquitinase activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameUSP8
Protein nameUSP8 protein
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Ubiquitin specific peptidase 8
SynonymsUBPY
KIAA0055
DescriptionFUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation . .

AccessionsQ05CD9
ENST00000560982.5
H0YKV1
ENST00000307179.9 [P40818-1]
H0YLH2
ENST00000561330.1
ENST00000560297.5
ENST00000558091.5
H0YM17
A0A075B720
Q05DF5
ENST00000559329.5
ENST00000559242.5
H0YNL5
H0YLS3
ENST00000425032.7 [P40818-2]
ENST00000396444.7 [P40818-1]
P40818
ENST00000560730.5
ENST00000625664.2
ENST00000561211.5
H0YM47