LGR5 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte	13 studies	30% ± 8%	Explore
oligodendrocyte precursor cell	5 studies	32% ± 17%	Explore

Name	Number of supported studies	Average coverage
brain	4 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	49%	295.43	469 / 966	80%	39.25	424 / 527
brain	73%	366.50	1919 / 2642	51%	5.27	362 / 705
ovary	59%	157.28	107 / 180	64%	26.38	277 / 430
adrenal gland	83%	333.76	214 / 258	37%	8.04	84 / 230
stomach	48%	107.86	171 / 359	69%	30.35	197 / 286
muscle	99%	3019.18	795 / 803	0%	0	0 / 0
lung	56%	127.38	322 / 578	26%	6.95	295 / 1155
blood vessel	78%	345.43	1047 / 1335	0%	0	0 / 0
breast	68%	214.71	311 / 459	7%	1.80	73 / 1118
skin	63%	503.18	1141 / 1809	3%	1.07	14 / 472
liver	23%	35.58	52 / 226	27%	5.46	110 / 406
adipose	49%	210.29	584 / 1204	0%	0	0 / 0
esophagus	6%	14.26	89 / 1445	39%	9.99	72 / 183
uterus	21%	127.11	35 / 170	24%	10.15	109 / 459
bladder	5%	9.10	1 / 21	31%	15.24	158 / 504
prostate	32%	103.98	79 / 245	3%	0.13	13 / 502
thymus	29%	54.23	191 / 653	4%	0.49	25 / 605
pancreas	0%	0	0 / 328	29%	3.73	52 / 178
tonsil	0%	0	0 / 0	24%	3.39	11 / 45
kidney	15%	42.71	13 / 89	2%	0.77	16 / 901
heart	7%	10.93	57 / 861	0%	0	0 / 0
peripheral blood	0%	0.29	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007190	Biological process	activation of adenylate cyclase activity
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_2001013	Biological process	epithelial cell proliferation involved in renal tubule morphogenesis
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0048839	Biological process	inner ear development
GO_0042127	Biological process	regulation of cell population proliferation
GO_0001942	Biological process	hair follicle development
GO_0009994	Biological process	oocyte differentiation
GO_0007189	Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0032588	Cellular component	trans-Golgi network membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0005886	Cellular component	plasma membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0016500	Molecular function	protein-hormone receptor activity
GO_0008528	Molecular function	G protein-coupled peptide receptor activity
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0005515	Molecular function	protein binding

Gene name	LGR5
Protein name	Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) G protein-coupled receptor 49 (Leucine-rich repeat-containing G protein-coupled receptor 5, isoform CRA_b)
Synonyms	GPR67 hCG_23766 GPR49
Description	FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. .
Accessions	A0A0A8K8C7 O75473 ENST00000536515.5 [O75473-3] ENST00000540815.2 [O75473-2] ENST00000266674.10 [O75473-1]

LGR5 report