PTK7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0060026Biological processconvergent extension
GO_0045198Biological processestablishment of epithelial cell apical/basal polarity
GO_0003401Biological processaxis elongation
GO_0010976Biological processpositive regulation of neuron projection development
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0007165Biological processsignal transduction
GO_0001822Biological processkidney development
GO_0060976Biological processcoronary vasculature development
GO_0003281Biological processventricular septum development
GO_0090103Biological processcochlea morphogenesis
GO_0090179Biological processplanar cell polarity pathway involved in neural tube closure
GO_0042060Biological processwound healing
GO_0030036Biological processactin cytoskeleton organization
GO_0001736Biological processestablishment of planar polarity
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0060484Biological processlung-associated mesenchyme development
GO_0050808Biological processsynapse organization
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0016477Biological processcell migration
GO_0007411Biological processaxon guidance
GO_0005886Cellular componentplasma membrane
GO_0043025Cellular componentneuronal cell body
GO_0005925Cellular componentfocal adhesion
GO_0005911Cellular componentcell-cell junction
GO_0030424Cellular componentaxon
GO_0015026Molecular functioncoreceptor activity
GO_0008046Molecular functionaxon guidance receptor activity
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePTK7
Protein nameTyrosine-protein kinase-like otk (Tyrosine-protein kinase-like 7 homolog)
PTK7 protein (Protein tyrosine kinase 7 (inactive))
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Protein tyrosine kinase 7 (inactive)
SynonymsCCK4
DescriptionFUNCTION: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. .

FUNCTION: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons. .

FUNCTION: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons. .

AccessionsENST00000352931.6 [Q13308-4]
ENST00000461389.1
ENST00000230419.9 [Q13308-1]
ENST00000345201.6 [Q13308-2]
C9JQR6
F8WCI7
ENST00000476760.1
Q13308
Q86X91
ENST00000481946.5
ENST00000470019.5
H7C4X3
ENST00000473339.1
ENST00000230418.8 [Q13308-5]
ENST00000349241.6 [Q13308-3]
ENST00000471863.5
ENST00000489707.5
ENST00000494146.5
ENST00000497957.1
H0Y889
H7C5L0
ENST00000461100.5
H0Y8F1
C9J9E8
F8WDG7
ENST00000481273.5 [Q13308-6]