HHEX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010621Biological processnegative regulation of transcription by transcription factor localization
GO_0030948Biological processnegative regulation of vascular endothelial growth factor receptor signaling pathway
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0016525Biological processnegative regulation of angiogenesis
GO_0006406Biological processmRNA export from nucleus
GO_0071103Biological processDNA conformation change
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0034504Biological processprotein localization to nucleus
GO_0009952Biological processanterior/posterior pattern specification
GO_0016055Biological processWnt signaling pathway
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0070663Biological processregulation of leukocyte proliferation
GO_0016973Biological processpoly(A)+ mRNA export from nucleus
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0030183Biological processB cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032993Cellular componentprotein-DNA complex
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0017025Molecular functionTBP-class protein binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0008301Molecular functionDNA binding, bending
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0008190Molecular functioneukaryotic initiation factor 4E binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHHEX
Protein nameHematopoietically expressed homeobox
Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Proline-rich homeodomain protein)
SynonymsHEX
PRHX
PRH
DescriptionFUNCTION: Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 . Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export . May play a role in hematopoietic differentiation . .

AccessionsENST00000282728.10
Q03014
F8VU08
ENST00000472590.6
ENST00000492654.3