DAPK3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DAPK3 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0097190Biological processapoptotic signaling pathway
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0006940Biological processregulation of smooth muscle contraction
GO_0071346Biological processcellular response to type II interferon
GO_0035556Biological processintracellular signal transduction
GO_0042981Biological processregulation of apoptotic process
GO_0010506Biological processregulation of autophagy
GO_0030335Biological processpositive regulation of cell migration
GO_0007346Biological processregulation of mitotic cell cycle
GO_0006355Biological processregulation of DNA-templated transcription
GO_2000145Biological processregulation of cell motility
GO_0043519Biological processregulation of myosin II filament organization
GO_0051893Biological processregulation of focal adhesion assembly
GO_0006915Biological processapoptotic process
GO_0008360Biological processregulation of cell shape
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0017148Biological processnegative regulation of translation
GO_0007088Biological processregulation of mitotic nuclear division
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0043522Molecular functionleucine zipper domain binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005524Molecular functionATP binding
GO_0008140Molecular functioncAMP response element binding protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDAPK3
Protein nameDeath associated protein kinase 3
Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase)
SynonymsZIPK
DescriptionFUNCTION: Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. .

AccessionsENST00000601824.1
ENST00000594894.1
M0QYY8
M0QYW5
ENST00000545797.7 [O43293-1]
M0R0D0
ENST00000596311.5
O43293
ENST00000593844.1
ENST00000301264.7 [O43293-1]