PPM1B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	17 studies	21% ± 4%	Explore
oligodendrocyte	14 studies	47% ± 19%	Explore
endothelial cell	14 studies	25% ± 10%	Explore
astrocyte	13 studies	37% ± 15%	Explore
oligodendrocyte precursor cell	12 studies	45% ± 20%	Explore
fibroblast	11 studies	21% ± 5%	Explore
macrophage	11 studies	23% ± 8%	Explore
T cell	10 studies	20% ± 4%	Explore
glutamatergic neuron	10 studies	40% ± 25%	Explore
microglial cell	10 studies	28% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	21% ± 4%	Explore
adipocyte	9 studies	42% ± 10%	Explore
GABAergic neuron	8 studies	42% ± 20%	Explore
B cell	8 studies	24% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	7 studies	21% ± 4%	Explore
retinal rod cell	7 studies	30% ± 11%	Explore
epithelial cell	7 studies	34% ± 13%	Explore
CD4-positive, alpha-beta T cell	6 studies	23% ± 4%	Explore
interneuron	6 studies	40% ± 24%	Explore
myeloid cell	6 studies	22% ± 4%	Explore
retina horizontal cell	6 studies	33% ± 13%	Explore
dendritic cell	6 studies	27% ± 12%	Explore
gamma-delta T cell	6 studies	25% ± 7%	Explore
type II pneumocyte	6 studies	22% ± 6%	Explore
smooth muscle cell	6 studies	20% ± 4%	Explore
classical monocyte	5 studies	23% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 4%	Explore
non-classical monocyte	5 studies	23% ± 8%	Explore
neuron	5 studies	34% ± 18%	Explore
retinal ganglion cell	5 studies	32% ± 14%	Explore
naive B cell	5 studies	18% ± 2%	Explore
Mueller cell	5 studies	24% ± 8%	Explore
type I pneumocyte	5 studies	22% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	18% ± 1%	Explore
regulatory T cell	5 studies	18% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
mucosal invariant T cell	4 studies	20% ± 3%	Explore
amacrine cell	4 studies	26% ± 5%	Explore
retinal cone cell	4 studies	28% ± 7%	Explore
cardiac muscle cell	4 studies	20% ± 3%	Explore
mast cell	4 studies	20% ± 6%	Explore
mononuclear phagocyte	4 studies	23% ± 3%	Explore
club cell	4 studies	22% ± 6%	Explore
monocyte	4 studies	28% ± 7%	Explore
pericyte	4 studies	18% ± 2%	Explore
mature NK T cell	3 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
GABAergic interneuron	3 studies	23% ± 2%	Explore
glial cell	3 studies	23% ± 3%	Explore
retinal pigment epithelial cell	3 studies	56% ± 15%	Explore
ciliated cell	3 studies	31% ± 6%	Explore
lymphocyte	3 studies	23% ± 2%	Explore
GABAergic amacrine cell	3 studies	31% ± 10%	Explore
glycinergic amacrine cell	3 studies	22% ± 4%	Explore
hepatocyte	3 studies	41% ± 13%	Explore
abnormal cell	3 studies	27% ± 9%	Explore
enteroendocrine cell	3 studies	23% ± 8%	Explore
leukocyte	3 studies	19% ± 5%	Explore
myofibroblast cell	3 studies	26% ± 6%	Explore
alveolar macrophage	3 studies	34% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 4%	Explore
goblet cell	3 studies	20% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	39% ± 22%	Explore
lung	7 studies	20% ± 5%	Explore
eye	6 studies	29% ± 7%	Explore
peripheral blood	4 studies	23% ± 5%	Explore
liver	4 studies	28% ± 9%	Explore
intestine	3 studies	20% ± 4%	Explore
adipose	3 studies	24% ± 5%	Explore
heart	3 studies	19% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	3567.76	459 / 459	100%	12.81	1118 / 1118
esophagus	100%	3910.89	1445 / 1445	100%	13.16	183 / 183
ovary	100%	2926.97	180 / 180	100%	9.58	430 / 430
pancreas	100%	1870.09	328 / 328	100%	11.65	178 / 178
uterus	100%	3392.38	170 / 170	100%	12.50	459 / 459
brain	100%	4784.95	2641 / 2642	100%	17.48	705 / 705
thymus	100%	2870.97	652 / 653	100%	11.33	604 / 605
prostate	100%	4070.23	244 / 245	100%	18.50	502 / 502
kidney	100%	2272.62	89 / 89	99%	8.49	895 / 901
liver	100%	2207.47	225 / 226	100%	11.12	405 / 406
lung	99%	3267.52	574 / 578	100%	11.81	1155 / 1155
stomach	100%	2800.07	359 / 359	99%	9.92	284 / 286
bladder	100%	3306.05	21 / 21	99%	11.38	500 / 504
adrenal gland	100%	2299.91	258 / 258	99%	9.86	228 / 230
intestine	100%	3294.95	966 / 966	98%	10.53	517 / 527
skin	100%	2719.80	1807 / 1809	97%	8.60	456 / 472
adipose	100%	3965.42	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5552.32	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	12.77	29 / 29
muscle	100%	10896.82	803 / 803	0%	0	0 / 0
spleen	100%	2964.29	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	8.90	45 / 45
ureter	0%	0	0 / 0	100%	6.66	1 / 1
heart	94%	2315.75	806 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	5.91	74 / 80
peripheral blood	82%	2009.23	765 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032688	Biological process	negative regulation of interferon-beta production
GO_0035970	Biological process	peptidyl-threonine dephosphorylation
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0006470	Biological process	protein dephosphorylation
GO_0050687	Biological process	negative regulation of defense response to virus
GO_0006499	Biological process	N-terminal protein myristoylation
GO_1901223	Biological process	negative regulation of non-canonical NF-kappaB signal transduction
GO_0043124	Biological process	negative regulation of canonical NF-kappaB signal transduction
GO_0005730	Cellular component	nucleolus
GO_0005634	Cellular component	nucleus
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0030145	Molecular function	manganese ion binding
GO_0005515	Molecular function	protein binding
GO_0017018	Molecular function	myosin phosphatase activity
GO_0000287	Molecular function	magnesium ion binding
GO_0004722	Molecular function	protein serine/threonine phosphatase activity

IV. Literature review

[source]

Gene name	PPM1B
Protein name	protein-serine/threonine phosphatase (EC 3.1.3.16) Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)
Synonyms	PP2CB
Description	FUNCTION: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. .
Accessions	ENST00000282412.9 [O75688-1] ENST00000409473.2 C9JIR6 ENST00000409432.7 [O75688-4] B8ZZF0 O75688 ENST00000345249.8 [O75688-3] ENST00000419807.5 Q4J6C0 ENST00000378551.6 [O75688-2]

PPM1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review