RSPO1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RSPO1 at tissue level.

III. Associated gene sets

GO_0016055Biological processWnt signaling pathway
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0002090Biological processregulation of receptor internalization
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0005576Cellular componentextracellular region
GO_0005634Cellular componentnucleus
GO_0008201Molecular functionheparin binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0001664Molecular functionG protein-coupled receptor binding

IV. Literature review

[source]
Gene nameRSPO1
Protein nameR-spondin-1 (Roof plate-specific spondin-1) (hRspo1)
Synonyms
DescriptionFUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors . Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 . .

AccessionsENST00000615459.4 [Q2MKA7-2]
ENST00000612451.4 [Q2MKA7-3]
ENST00000356545.7 [Q2MKA7-1]
ENST00000401068.1 [Q2MKA7-1]
Q2MKA7