NFKB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010744Biological processpositive regulation of macrophage derived foam cell differentiation
GO_0006366Biological processtranscription by RNA polymerase II
GO_0007254Biological processJNK cascade
GO_0035994Biological processresponse to muscle stretch
GO_0006954Biological processinflammatory response
GO_0033554Biological processcellular response to stress
GO_0071260Biological processcellular response to mechanical stimulus
GO_0097398Biological processcellular response to interleukin-17
GO_0010629Biological processnegative regulation of gene expression
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0045087Biological processinnate immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0034097Biological processresponse to cytokine
GO_0010956Biological processnegative regulation of calcidiol 1-monooxygenase activity
GO_0071359Biological processcellular response to dsRNA
GO_0050853Biological processB cell receptor signaling pathway
GO_0032695Biological processnegative regulation of interleukin-12 production
GO_0071347Biological processcellular response to interleukin-1
GO_2000630Biological processpositive regulation of miRNA metabolic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0060056Biological processmammary gland involution
GO_0032375Biological processnegative regulation of cholesterol transport
GO_0140367Biological processantibacterial innate immune response
GO_0098586Biological processcellular response to virus
GO_0051248Biological processnegative regulation of protein metabolic process
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0050728Biological processnegative regulation of inflammatory response
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006915Biological processapoptotic process
GO_0071316Biological processcellular response to nicotine
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_1900127Biological processpositive regulation of hyaluronan biosynthetic process
GO_0010884Biological processpositive regulation of lipid storage
GO_0010957Biological processnegative regulation of vitamin D biosynthetic process
GO_0071354Biological processcellular response to interleukin-6
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_1904385Biological processcellular response to angiotensin
GO_0005576Cellular componentextracellular region
GO_0035525Cellular componentNF-kappaB p50/p65 complex
GO_0005739Cellular componentmitochondrion
GO_0033256Cellular componentI-kappaB/NF-kappaB complex
GO_0005654Cellular componentnucleoplasm
GO_0034774Cellular componentsecretory granule lumen
GO_0005829Cellular componentcytosol
GO_0035580Cellular componentspecific granule lumen
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0042802Molecular functionidentical protein binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0042805Molecular functionactinin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNFKB1
Protein nameNuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Nuclear factor NF-kappa-B p105 subunit
Nuclear factor kappa B subunit 1
Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1)
Synonyms
DescriptionFUNCTION: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. .; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B . Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 . .; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor . Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions . .

AccessionsENST00000509165.1
A0A8V8TLB2
ENST00000394820.8 [P19838-1]
P19838
ENST00000652569.1
ENST00000697794.1
ENST00000507079.6
ENST00000226574.9 [P19838-2]
ENST00000652619.1
ENST00000509165.2 [P19838-2]
D6RC45
A0A494C157
A0A494C1E9
D6RH30
ENST00000505458.5 [P19838-1]