DLX5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DLX5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DLX5 at tissue level.

III. Associated gene sets

GO_0009790Biological processembryo development
GO_0060166Biological processolfactory pit development
GO_0008283Biological processcell population proliferation
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0030855Biological processepithelial cell differentiation
GO_0001649Biological processosteoblast differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0001958Biological processendochondral ossification
GO_0097376Biological processinterneuron axon guidance
GO_0030509Biological processBMP signaling pathway
GO_0060021Biological processroof of mouth development
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0048646Biological processanatomical structure formation involved in morphogenesis
GO_0030154Biological processcell differentiation
GO_0030326Biological processembryonic limb morphogenesis
GO_0042472Biological processinner ear morphogenesis
GO_0021889Biological processolfactory bulb interneuron differentiation
GO_0001501Biological processskeletal system development
GO_0060325Biological processface morphogenesis
GO_0007399Biological processnervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0071837Molecular functionHMG box domain binding

IV. Literature review

[source]
Gene nameDLX5
Protein nameDistal-less homeo box 5 (Distal-less homeobox 5)
Homeobox protein DLX-5
SynonymshCG_40634
tcag7.302
DescriptionFUNCTION: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. .

AccessionsENST00000648378.1 [P56178-1]
Q53Y73
ENST00000486603.2 [P56178-2]
P56178