UBR5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071629Biological processcytoplasm protein quality control by the ubiquitin-proteasome system
GO_0006281Biological processDNA repair
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0010628Biological processpositive regulation of gene expression
GO_0006974Biological processDNA damage response
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0050847Biological processprogesterone receptor signaling pathway
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0071630Biological processnuclear protein quality control by the ubiquitin-proteasome system
GO_0033696Biological processheterochromatin boundary formation
GO_0035519Biological processprotein K29-linked ubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0140455Biological processcytoplasm protein quality control
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0034450Molecular functionubiquitin-ubiquitin ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameUBR5
Protein nameAlternative protein UBR5
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Ubiquitin protein ligase E3 component n-recognin 5
UBR5 protein
SynonymsKIAA0896
EDD1
HYD
EDD
DescriptionFUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. .

AccessionsENST00000220959.8 [O95071-2]
H0YBB4
Q49A65
ENST00000521922.5
ENST00000521566.1
E7ET84
ENST00000518205.5
H0YAV7
O95071
E7EMW7
L8E894
ENST00000520898.5
ENST00000520539.6 [O95071-1]
E5RFK7
ENST00000519365.1