RUVBL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0006281Biological processDNA repair
GO_0007283Biological processspermatogenesis
GO_0045995Biological processregulation of embryonic development
GO_2000779Biological processregulation of double-strand break repair
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0045739Biological processpositive regulation of DNA repair
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006282Biological processregulation of DNA repair
GO_1904874Biological processpositive regulation of telomerase RNA localization to Cajal body
GO_0060382Biological processregulation of DNA strand elongation
GO_1904507Biological processpositive regulation of telomere maintenance in response to DNA damage
GO_0051301Biological processcell division
GO_0006338Biological processchromatin remodeling
GO_0042981Biological processregulation of apoptotic process
GO_0000492Biological processbox C/D snoRNP assembly
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0050821Biological processprotein stabilization
GO_0006355Biological processregulation of DNA-templated transcription
GO_0000723Biological processtelomere maintenance
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0033044Biological processregulation of chromosome organization
GO_0006310Biological processDNA recombination
GO_0006275Biological processregulation of DNA replication
GO_0051726Biological processregulation of cell cycle
GO_0000812Cellular componentSwr1 complex
GO_0071339Cellular componentMLL1 complex
GO_0000786Cellular componentnucleosome
GO_1990062Cellular componentRPAP3/R2TP/prefoldin-like complex
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0016363Cellular componentnuclear matrix
GO_0120293Cellular componentdynein axonemal particle
GO_0101031Cellular componentprotein folding chaperone complex
GO_0005829Cellular componentcytosol
GO_0097255Cellular componentR2TP complex
GO_1990904Cellular componentribonucleoprotein complex
GO_0031011Cellular componentIno80 complex
GO_0005634Cellular componentnucleus
GO_0017025Molecular functionTBP-class protein binding
GO_0043531Molecular functionADP binding
GO_0001094Molecular functionTFIID-class transcription factor complex binding
GO_0045296Molecular functioncadherin binding
GO_0003678Molecular functionDNA helicase activity
GO_0005524Molecular functionATP binding
GO_0051117Molecular functionATPase binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameRUVBL1
Protein nameRuvB-like helicase (EC 3.6.4.12)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
SynonymsTIP49A
TIP49
INO80H
NMP238
DescriptionFUNCTION: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity . Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A . This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription . This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair . The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage . Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome . Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding . Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex . Essential for cell proliferation . May be able to bind plasminogen at cell surface and enhance plasminogen activation . .

FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. .

FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. .

FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. .

FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. .

FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. .

AccessionsENST00000585057.5
H7C4G5
H7C4I3
J3QLR1
ENST00000322623.10 [Q9Y265-1]
ENST00000464873.5
ENST00000472125.5
ENST00000478892.1
E7ETR0
Q9Y265
B5BUB1