VPS35 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0090326Biological processpositive regulation of locomotion involved in locomotory behavior
GO_0032463Biological processnegative regulation of protein homooligomerization
GO_0050882Biological processvoluntary musculoskeletal movement
GO_1904377Biological processpositive regulation of protein localization to cell periphery
GO_0060161Biological processpositive regulation of dopamine receptor signaling pathway
GO_0010821Biological processregulation of mitochondrion organization
GO_0090141Biological processpositive regulation of mitochondrial fission
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_1905606Biological processregulation of presynapse assembly
GO_0150052Biological processregulation of postsynapse assembly
GO_0010629Biological processnegative regulation of gene expression
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_1905166Biological processnegative regulation of lysosomal protein catabolic process
GO_0010628Biological processpositive regulation of gene expression
GO_0006886Biological processintracellular protein transport
GO_0090128Biological processregulation of synapse maturation
GO_1902823Biological processnegative regulation of late endosome to lysosome transport
GO_1903181Biological processpositive regulation of dopamine biosynthetic process
GO_0031648Biological processprotein destabilization
GO_0032456Biological processendocytic recycling
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0031647Biological processregulation of protein stability
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0043653Biological processmitochondrial fragmentation involved in apoptotic process
GO_0050728Biological processnegative regulation of inflammatory response
GO_0098887Biological processneurotransmitter receptor transport, endosome to postsynaptic membrane
GO_0099074Biological processmitochondrion to lysosome vesicle-mediated transport
GO_0061357Biological processpositive regulation of Wnt protein secretion
GO_1902950Biological processregulation of dendritic spine maintenance
GO_0099639Biological processneurotransmitter receptor transport, endosome to plasma membrane
GO_0045056Biological processtranscytosis
GO_0099003Biological processvesicle-mediated transport in synapse
GO_0016055Biological processWnt signaling pathway
GO_0016241Biological processregulation of macroautophagy
GO_0051246Biological processregulation of protein metabolic process
GO_1903828Biological processnegative regulation of protein localization
GO_2000331Biological processregulation of terminal button organization
GO_0036010Biological processprotein localization to endosome
GO_0098978Cellular componentglutamatergic synapse
GO_0098793Cellular componentpresynapse
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030906Cellular componentretromer, cargo-selective complex
GO_0005739Cellular componentmitochondrion
GO_0005769Cellular componentearly endosome
GO_0097422Cellular componenttubular endosome
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0043025Cellular componentneuronal cell body
GO_0098691Cellular componentdopaminergic synapse
GO_0043005Cellular componentneuron projection
GO_0030904Cellular componentretromer complex
GO_0005829Cellular componentcytosol
GO_0099073Cellular componentmitochondrion-derived vesicle
GO_0014069Cellular componentpostsynaptic density
GO_0005770Cellular componentlate endosome
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005765Cellular componentlysosomal membrane
GO_0031748Molecular functionD1 dopamine receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVPS35
Protein nameVacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35)
VPS35 retromer complex component
SynonymsTCCCTA00141
MEM3
DescriptionFUNCTION: Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway . The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) . Required for endosomal localization of WASHC2C . Mediates the association of the CSC with the WASH complex via WASHC2 . Required for the endosomal localization of TBC1D5 . .; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. .

AccessionsQ96QK1
ENST00000647959.1
I3L4S0
ENST00000568612.5
A0A3B3ITD4
ENST00000568784.6
ENST00000299138.12
H3BRJ7