SOX4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	37 studies	42% ± 19%	Explore
endothelial cell	26 studies	41% ± 21%	Explore
pericyte	26 studies	43% ± 24%	Explore
plasmacytoid dendritic cell	24 studies	58% ± 16%	Explore
smooth muscle cell	21 studies	44% ± 20%	Explore
mast cell	18 studies	30% ± 15%	Explore
ciliated cell	18 studies	45% ± 21%	Explore
basal cell	17 studies	45% ± 19%	Explore
epithelial cell	17 studies	48% ± 23%	Explore
endothelial cell of lymphatic vessel	16 studies	48% ± 20%	Explore
connective tissue cell	16 studies	54% ± 23%	Explore
myofibroblast cell	14 studies	52% ± 24%	Explore
conventional dendritic cell	13 studies	31% ± 20%	Explore
secretory cell	12 studies	43% ± 18%	Explore
type I pneumocyte	10 studies	37% ± 20%	Explore
club cell	10 studies	50% ± 24%	Explore
progenitor cell	10 studies	51% ± 22%	Explore
endothelial cell of vascular tree	10 studies	29% ± 10%	Explore
non-classical monocyte	9 studies	23% ± 9%	Explore
abnormal cell	9 studies	46% ± 21%	Explore
oligodendrocyte precursor cell	9 studies	40% ± 18%	Explore
macrophage	8 studies	27% ± 8%	Explore
respiratory goblet cell	8 studies	46% ± 20%	Explore
classical monocyte	8 studies	26% ± 10%	Explore
capillary endothelial cell	8 studies	39% ± 22%	Explore
mesothelial cell	8 studies	56% ± 25%	Explore
vein endothelial cell	8 studies	46% ± 23%	Explore
dendritic cell	7 studies	34% ± 13%	Explore
ionocyte	7 studies	66% ± 18%	Explore
endothelial cell of artery	7 studies	41% ± 23%	Explore
goblet cell	7 studies	30% ± 18%	Explore
neuron	7 studies	71% ± 29%	Explore
hematopoietic stem cell	7 studies	67% ± 13%	Explore
brush cell	7 studies	68% ± 25%	Explore
B cell	6 studies	46% ± 21%	Explore
interneuron	6 studies	48% ± 26%	Explore
astrocyte	6 studies	44% ± 16%	Explore
precursor B cell	6 studies	77% ± 14%	Explore
immature B cell	6 studies	54% ± 22%	Explore
monocyte	5 studies	24% ± 5%	Explore
kidney loop of Henle epithelial cell	5 studies	33% ± 11%	Explore
enteroendocrine cell	5 studies	51% ± 12%	Explore
intestinal crypt stem cell	5 studies	43% ± 15%	Explore
glial cell	5 studies	41% ± 27%	Explore
pro-B cell	5 studies	77% ± 12%	Explore
Mueller cell	5 studies	42% ± 14%	Explore
innate lymphoid cell	5 studies	24% ± 8%	Explore
glutamatergic neuron	5 studies	33% ± 31%	Explore
hematopoietic precursor cell	4 studies	74% ± 9%	Explore
deuterosomal cell	4 studies	48% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	65% ± 27%	Explore
CD4-positive, alpha-beta T cell	4 studies	47% ± 20%	Explore
T cell	4 studies	55% ± 34%	Explore
epithelial cell of proximal tubule	4 studies	34% ± 18%	Explore
leukocyte	4 studies	23% ± 8%	Explore
transit amplifying cell	4 studies	30% ± 9%	Explore
amacrine cell	4 studies	50% ± 28%	Explore
retinal bipolar neuron	4 studies	30% ± 15%	Explore
adventitial cell	4 studies	21% ± 7%	Explore
keratinocyte	4 studies	19% ± 3%	Explore
acinar cell	4 studies	48% ± 24%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	64% ± 6%	Explore
GABAergic neuron	4 studies	56% ± 36%	Explore
type II pneumocyte	3 studies	38% ± 23%	Explore
duct epithelial cell	3 studies	36% ± 3%	Explore
precursor cell	3 studies	69% ± 21%	Explore
squamous epithelial cell	3 studies	57% ± 19%	Explore
mononuclear phagocyte	3 studies	27% ± 10%	Explore
neural crest cell	3 studies	68% ± 21%	Explore
glycinergic amacrine cell	3 studies	42% ± 24%	Explore
renal principal cell	3 studies	42% ± 11%	Explore
extravillous trophoblast	3 studies	54% ± 10%	Explore
lymphocyte	3 studies	42% ± 20%	Explore
myeloid cell	3 studies	29% ± 13%	Explore
neuroendocrine cell	3 studies	73% ± 29%	Explore
CD8-positive, alpha-beta T cell	3 studies	48% ± 21%	Explore
Schwann cell	3 studies	68% ± 17%	Explore
retina horizontal cell	3 studies	56% ± 25%	Explore
chondrocyte	3 studies	43% ± 24%	Explore
muscle cell	3 studies	21% ± 6%	Explore
myoepithelial cell	3 studies	50% ± 6%	Explore
pancreatic ductal cell	3 studies	82% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	72% ± 17%	Explore
mucus secreting cell	3 studies	26% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	42% ± 19%	Explore
melanocyte	3 studies	29% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	44% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	38% ± 23%	Explore
intestine	9 studies	37% ± 22%	Explore
kidney	6 studies	33% ± 18%	Explore
eye	6 studies	39% ± 16%	Explore
uterus	6 studies	33% ± 21%	Explore
pancreas	5 studies	27% ± 7%	Explore
brain	5 studies	37% ± 11%	Explore
placenta	4 studies	24% ± 8%	Explore
prostate	4 studies	20% ± 4%	Explore
breast	4 studies	37% ± 9%	Explore
ovary	3 studies	37% ± 12%	Explore
skin	3 studies	27% ± 6%	Explore
thymus	3 studies	67% ± 25%	Explore
bone marrow	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	3885.39	459 / 459	99%	175.29	1108 / 1118
prostate	100%	2740.96	245 / 245	99%	94.24	496 / 502
lung	100%	3236.34	576 / 578	99%	156.51	1139 / 1155
ovary	100%	9283.14	180 / 180	98%	146.95	422 / 430
intestine	100%	1664.35	964 / 966	98%	109.08	514 / 527
stomach	100%	2236.31	359 / 359	97%	117.81	278 / 286
bladder	100%	2154.62	21 / 21	96%	157.57	486 / 504
esophagus	99%	1100.49	1430 / 1445	96%	128.84	175 / 183
uterus	100%	5449.45	170 / 170	94%	129.62	430 / 459
pancreas	98%	1813.40	323 / 328	94%	92.24	167 / 178
thymus	100%	2278.39	652 / 653	92%	118.26	559 / 605
kidney	100%	2339.99	89 / 89	84%	72.91	753 / 901
skin	99%	2117.69	1796 / 1809	83%	86.19	394 / 472
brain	90%	817.94	2372 / 2642	92%	180.20	647 / 705
adrenal gland	96%	733.17	247 / 258	41%	19.11	94 / 230
ureter	0%	0	0 / 0	100%	98.88	1 / 1
adipose	100%	2693.75	1203 / 1204	0%	0	0 / 0
blood vessel	99%	1538.79	1318 / 1335	0%	0	0 / 0
spleen	98%	874.45	237 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	86.01	38 / 45
heart	83%	767.70	715 / 861	0%	0	0 / 0
liver	35%	392.02	80 / 226	31%	28.90	125 / 406
eye	0%	0	0 / 0	61%	40.10	49 / 80
peripheral blood	29%	521.10	266 / 929	0%	0	0 / 0
muscle	26%	159.99	211 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	21%	11.09	6 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0021782	Biological process	glial cell development
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0071333	Biological process	cellular response to glucose stimulus
GO_0035910	Biological process	ascending aorta morphogenesis
GO_2000761	Biological process	positive regulation of N-terminal peptidyl-lysine acetylation
GO_0021510	Biological process	spinal cord development
GO_0048485	Biological process	sympathetic nervous system development
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0007507	Biological process	heart development
GO_0043516	Biological process	regulation of DNA damage response, signal transduction by p53 class mediator
GO_0048593	Biological process	camera-type eye morphogenesis
GO_0003183	Biological process	mitral valve morphogenesis
GO_0045662	Biological process	negative regulation of myoblast differentiation
GO_0045663	Biological process	positive regulation of myoblast differentiation
GO_0045588	Biological process	positive regulation of gamma-delta T cell differentiation
GO_0003357	Biological process	noradrenergic neuron differentiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0003215	Biological process	cardiac right ventricle morphogenesis
GO_0032024	Biological process	positive regulation of insulin secretion
GO_0061484	Biological process	hematopoietic stem cell homeostasis
GO_0031647	Biological process	regulation of protein stability
GO_0030217	Biological process	T cell differentiation
GO_0030182	Biological process	neuron differentiation
GO_0060485	Biological process	mesenchyme development
GO_0031397	Biological process	negative regulation of protein ubiquitination
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0060563	Biological process	neuroepithelial cell differentiation
GO_0050821	Biological process	protein stabilization
GO_0001666	Biological process	response to hypoxia
GO_0002328	Biological process	pro-B cell differentiation
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0060412	Biological process	ventricular septum morphogenesis
GO_0045727	Biological process	positive regulation of translation
GO_0007420	Biological process	brain development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0031018	Biological process	endocrine pancreas development
GO_0010467	Biological process	gene expression
GO_0060993	Biological process	kidney morphogenesis
GO_0003289	Biological process	atrial septum primum morphogenesis
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0007399	Biological process	nervous system development
GO_0014009	Biological process	glial cell proliferation
GO_0042593	Biological process	glucose homeostasis
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0035198	Molecular function	miRNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SOX4
Protein name	Transcription factor SOX-4
Synonyms
Description	FUNCTION: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif . Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 . .
Accessions	Q06945 ENST00000244745.4

SOX4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review