KANK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035024Biological processnegative regulation of Rho protein signal transduction
GO_0030837Biological processnegative regulation of actin filament polymerization
GO_2000393Biological processnegative regulation of lamellipodium morphogenesis
GO_0008283Biological processcell population proliferation
GO_2000114Biological processregulation of establishment of cell polarity
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0030036Biological processactin cytoskeleton organization
GO_0010977Biological processnegative regulation of neuron projection development
GO_0035023Biological processregulation of Rho protein signal transduction
GO_0090521Biological processpodocyte cell migration
GO_1900025Biological processnegative regulation of substrate adhesion-dependent cell spreading
GO_0030336Biological processnegative regulation of cell migration
GO_1900028Biological processnegative regulation of ruffle assembly
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0090303Biological processpositive regulation of wound healing
GO_0032587Cellular componentruffle membrane
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0005737Cellular componentcytoplasm
GO_0008013Molecular functionbeta-catenin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKANK1
Protein nameKN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)
KN motif and ankyrin repeat domains 1
KANK1 protein
SynonymsKIAA0172
ANKRD15
KANK
DescriptionFUNCTION: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration . Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes . Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1 . Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways . .

AccessionsENST00000689214.1
ENST00000685947.1 [Q14678-1]
ENST00000687796.1 [Q14678-2]
ENST00000688039.1
A0A8I5KTS9
Q6PIB3
ENST00000685590.1
ENST00000382286.3
ENST00000692757.1
A0A8I5KNW9
A0A8I5KUI5
ENST00000693088.1
ENST00000382293.7 [Q14678-2]
ENST00000619269.5
A0A8J9BYE6
A0A8I5KT40
ENST00000382297.7 [Q14678-1]
ENST00000687662.1
ENST00000690372.1 [Q14678-2]
ENST00000693021.1
ENST00000690348.1
ENST00000693143.1
ENST00000691319.1
ENST00000382289.7
Q8WUM7
ENST00000674102.1 [Q14678-1]
A0A8I5KVK4
ENST00000685380.1
ENST00000691645.1
A0A8I5KP85
Q5W0W2
ENST00000382303.5 [Q14678-1]
ENST00000689926.1
A0A8I5KRP2
ENST00000689779.1 [Q14678-1]
A0A8I5KZ49
A0A8I5KUD8
A0A8I5KSV2
Q14678
A0A8I5KUM3
Q5W0W3
A0A8I5QKT2
A0A8I5KXH8
ENST00000692345.1