I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 11 studies | 61% ± 14% | |
| squamous epithelial cell | 4 studies | 70% ± 13% | |
| epithelial cell | 4 studies | 42% ± 16% | |
| basal cell | 4 studies | 26% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 11 studies | 61% ± 14% | |
| squamous epithelial cell | 4 studies | 70% ± 13% | |
| epithelial cell | 4 studies | 42% ± 16% | |
| basal cell | 4 studies | 26% ± 9% |
Insufficient scRNA-seq data for expression of SCEL at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 93% | 6112.85 | 536 / 578 | 66% | 25.20 | 758 / 1155 |
| esophagus | 40% | 18182.01 | 574 / 1445 | 57% | 49.26 | 105 / 183 |
| skin | 72% | 19708.56 | 1302 / 1809 | 9% | 1.78 | 41 / 472 |
| thymus | 0% | 4.80 | 2 / 653 | 74% | 48.72 | 447 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 32.61 | 31 / 45 |
| pancreas | 0% | 4.80 | 1 / 328 | 65% | 16.72 | 115 / 178 |
| uterus | 1% | 360.99 | 2 / 170 | 54% | 19.63 | 247 / 459 |
| ovary | 0% | 0 | 0 / 180 | 37% | 5.50 | 157 / 430 |
| bladder | 0% | 0 | 0 / 21 | 26% | 8.33 | 129 / 504 |
| kidney | 0% | 0 | 0 / 89 | 19% | 8.90 | 167 / 901 |
| intestine | 0% | 0 | 0 / 966 | 15% | 6.54 | 81 / 527 |
| stomach | 1% | 82.85 | 3 / 359 | 10% | 2.64 | 29 / 286 |
| breast | 0% | 0 | 0 / 459 | 5% | 0.96 | 60 / 1118 |
| adipose | 4% | 113.79 | 49 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0 | 0 / 258 | 1% | 0.17 | 3 / 230 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.21 | 4 / 406 |
| muscle | 0% | 9.39 | 2 / 803 | 0% | 0 | 0 / 0 |
| prostate | 0% | 0 | 0 / 245 | 0% | 0.07 | 1 / 502 |
| blood vessel | 0% | 14.00 | 1 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| brain | 0% | 0 | 0 / 2642 | 0% | 0 | 0 / 705 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030216 | Biological process | keratinocyte differentiation |
| GO_0009612 | Biological process | response to mechanical stimulus |
| GO_0008544 | Biological process | epidermis development |
| GO_0009792 | Biological process | embryo development ending in birth or egg hatching |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_0001533 | Cellular component | cornified envelope |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | SCEL |
| Protein name | Sciellin |
| Synonyms | |
| Description | FUNCTION: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. |
| Accessions | ENST00000349847.4 [O95171-1] ENST00000377246.7 [O95171-2] ENST00000535157.5 [O95171-3] ENST00000471491.5 O95171 F2Z2X8 |
